2021
DOI: 10.1186/s13054-021-03861-6
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Hyperglycemia and insulin resistance in COVID-19 versus non-COVID critical illness: Are they really different?

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Cited by 16 publications
(11 citation statements)
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“…Patients with COVID-19, without any pre-existing history or diagnosis of diabetes, are reported to have a greater prevalence of hyperglycemia 7 . However, stress hyperglycemia and insulin resistance are also characteristics of other acute critical illnesses 8 . Therefore, it remains unclear whether COVID-19-associated hyperglycemia and insulin resistance is more severe than in non-COVID patients with similar disease severity.…”
Section: Introductionmentioning
confidence: 99%
“…Patients with COVID-19, without any pre-existing history or diagnosis of diabetes, are reported to have a greater prevalence of hyperglycemia 7 . However, stress hyperglycemia and insulin resistance are also characteristics of other acute critical illnesses 8 . Therefore, it remains unclear whether COVID-19-associated hyperglycemia and insulin resistance is more severe than in non-COVID patients with similar disease severity.…”
Section: Introductionmentioning
confidence: 99%
“…Reasons for this new-onset hyperglycemia upon COVID-19 hospitalization are many folds, including previously undiagnosed diabetes, usage of non-diabetic medications, and stress-induced transient rise in blood sugar levels ( 22 ). Besides, SARS-CoV-2 might attack the ACE2-expressed pancreatic islets to impair the endocrine balance, and the ensuing insulin deficiency/resistance could cause hyperglycemia as other non-COVID-19 critical illness did ( 23 , 24 ).…”
Section: Resultsmentioning
confidence: 99%
“…Likewise, COVID-19 predisposes infected patients to hyperglycemia, diabetic ketoacidosis, and new-onset diabetes [ 28 ]. This can lead to an endless loop of worsening hyperglycemia and COVID-19 infection [ 29 ].…”
Section: Discussionmentioning
confidence: 99%