Hyperglycemia after Acute Myocardial Infarction

Datey, K. K.; Nanda, Navin C.

doi:10.1056/nejm196702022760504

Cited by 63 publications

(12 citation statements)

References 6 publications

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“…His results are unusual in that no alteration of glucose tolerance was noticed whether tests were carried out 3-7 days or 3-6 weeks after the attack. This result is unusual as in all other studies, including the present, the disturbance of glucose tolerance is approximately inversely related to the time lapse between infarction and the glucose tolerance test (Dunnigan & Sawyers, 1965;Datey & Nanda, 1967). Cohen & Shafrir's (1965) finding of glucose intolerance in 770/o of thirty-three patients within 3 weeks of infarction accords with the results of the present study.…”

Section: Discussionsupporting

confidence: 90%

“…The prolonged metabolic disturbance following cardiac infarction is sufficient to depress glucose tolerance for some months (Datey & Nanda, 1967), and the results of tests in coronary disease must allow for this disturbance to settle and be interpreted with care in view ofthe uncertain significance of minor deviations from the so-called normal glucose tolerance curve.…”

Section: Discussionmentioning

confidence: 99%

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Intravenous glucose tolerance in myocardial infarction

Pearson¹

1971

Postgraduate Medical Journal

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SummaryIntravenous glucose tolerance tests were carried ont on forty patients with recent myocardial infarction and thirty-nine matched controls with recent bone injury.Abnormal results were detected in 77 5%4 of cardiac patients and 68% controls. When tests were repeated after acute stress factors had settled, normal results were obtained in 85%y of thirty-three cardiac subjects and 84%y of thirty-eight controls.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Intravenous glucose tolerance in myocardial infarction

Pearson¹

1971

Postgraduate Medical Journal

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“…Patients with acute myocardial infarction [5,39,43,89,93,111,129,138], burns [6,15], deep hypothermia [12,13] and patients undergoing surgery [108] show hyperglycaemia, impaired glucose tolerance and elevated free fatty acids. Insulin concentration is elevated but inappropriately low in relation to the blood glucose concentration.…”

Section: Role Of Catecholamines In the Regulation Of Insulin Secretionmentioning

confidence: 99%

Catecholamines and diabetes mellitus

Christensen

1979

Diabetologia

109

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“…Thus, hyperglycemia is seen, for instance, during myocardial infarction (1,2), severe infections (3), burns (4), and trauma (5). The release of stress hormones from the adrenal medulla is assumed to be important for the effects of stress on glycemic control (6).…”

mentioning

confidence: 99%

Influence of Circulating Epinephrine on Absorption of Subcutaneously Injected Insulin

1988

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Effects of epinephrine (Epi) infusion on the absorption of subcutaneously injected 125I-labeled soluble human insulin (10 U) from the thigh or the abdomen were studied in 16 healthy subjects and from the thigh in 10 insulin-dependent diabetic (IDDM) patients. Epi was infused at 0.3 (high dose) or 0.1 (low dose; healthy subjects) nmol.kg-1.min-1 i.v., resulting in arterial plasma Epi levels of approximately 6 and 2 nM, respectively. Saline was infused on a control day. Insulin absorption was measured as disappearance of radioactivity from the injection site and as appearance of plasma immunoreactive insulin (IRI). Adipose tissue blood flow was measured with the 133Xe clearance technique. First-order disappearance rate constants of 125I from the thigh depot decreased approximately 40-50% during the high dose of Epi compared with control (P less than .001). The corresponding decrease from the abdominal depot was approximately 40% (P less than .001), whereas no significant change was found during the low Epi dose. IRI fell compared with control in all groups at the high Epi dose. The Epi-induced depression of insulin absorption occurred despite unaltered or even slightly increased subcutaneous blood flow. The results indicate that circulating Epi at levels seen during moderate physical stress depresses the absorption of soluble insulin from subcutaneous injection sites to an extent that might be important for glycemic control in IDDM patients. Furthermore, dissociation is found between changes in insulin absorption and subcutaneous blood flow during Epi infusion, suggesting that factors other than blood flow may also influence the absorption of subcutaneously injected insulin.

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Hyperglycemia after Acute Myocardial Infarction

Cited by 63 publications

References 6 publications

Intravenous glucose tolerance in myocardial infarction

Intravenous glucose tolerance in myocardial infarction

Catecholamines and diabetes mellitus

Influence of Circulating Epinephrine on Absorption of Subcutaneously Injected Insulin

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