Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: Protective effect of 17β-estradiol

Hamden, Khaled; Carreau, Serge; Boujbiha, Mohamed Ali; Lajmi, Samiha; Aloulou, Dorra; Kchaou, Dalanda; Elfeki, Abdelfattah

doi:10.1016/j.steroids.2007.12.026

Cited by 66 publications

(45 citation statements)

References 30 publications

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“…Under these conditions, steatosis and necroinflammatory mechanisms are difficult to observe. [15][16][17][18] Ultrastructurally, the rough endoplasmic reticulum is significantly reduced in diabetic patients in comparison with the smooth endoplasmic reticulum. 9 Moreover, DM causes a marked increase in mitochondrial volume fraction with highly diminished densities of mitochondrial cristae, pyknotic nuclei with damaged nuclear membranes and the extension of the perinuclear area [ Figure 2].…”

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

“…9 Moreover, DM causes a marked increase in mitochondrial volume fraction with highly diminished densities of mitochondrial cristae, pyknotic nuclei with damaged nuclear membranes and the extension of the perinuclear area [ Figure 2]. [16][17][18][19] In addition, increased lipid accumulation and decreased glycogen content are also seen in the liver cells. [16][17][18][19] b i o c h e m i c a l c h a n g e s…”

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

“…[16][17][18][19] In addition, increased lipid accumulation and decreased glycogen content are also seen in the liver cells. [16][17][18][19] b i o c h e m i c a l c h a n g e s…”

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

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Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Mohamed¹,

Nafizah²,

Zariyantey³

et al. 2016

SQUMJ

345

199

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Diabetes mellitus is a non-communicable disease that occurs in both developed and developing countries. This metabolic disease affects all systems in the body, including the liver. Hyperglycaemia, mainly caused by insulin resistance, affects the metabolism of lipids, carbohydrates and proteins and can lead to nonalcoholic fatty liver disease, which can further progress to non-alcoholic steatohepatitis, cirrhosis and, finally, hepatocellular carcinomas. The underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes. Significant involvement of pro-inflammatory cytokinesincluding interleukin (IL)-1β, IL-6 and tumour necrosis factor-α-exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals.

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Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

Section: Mechanisms Of Diabetes-induced Liver Damagementioning

confidence: 99%

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Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Mohamed¹,

Nafizah²,

Zariyantey³

et al. 2016

SQUMJ

345

199

View full text Add to dashboard Cite

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“…Insulin resistance, which occurs in several key tissues such as liver, muscles, and adipose tissue, is the primary cause of hyperglycemia and a hallmark in T2D pathogenesis [72]. Another wellknown mechanism that affects glucose homeostasis is oxidative stress, which is driven by autooxidation and protein glycation [73].…”

Section: Anti-hyperglycemic Actionsmentioning

confidence: 99%

The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

2016

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■ AbstractThe tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. The Taraxacum genus from the Asteraceae family is found in the temperate zone of the Northern hemisphere. It is available in several areas around the world. In many countries, it is used as food and in some countries as therapeutics for the control and treatment of T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, and sesquiterpene lactones. Studies have outlined the useful pharmacological profile of dandelion for the treatment of an array of diseases, although little attention has been paid to the effects of its bioactive components on T2D to date. This review recapitulates previous work on dandelion and its potential for the treatment and prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, and their potential mechanisms of action in T2D. Although initial research appears promising, data on the cellular impact of dandelion are limited, necessitating further work on clonal β-cell lines (INS-1E), α-cell lines, and human skeletal cell lines for better identification of the active components that could be of use in the control and treatment of T2D. In fact, extensive invitro, in-vivo, and clinical research is required to investigate further the pharmacological, physiological, and biochemical mechanisms underlying the effects of dandelion-derived compounds on T2D.

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“…A large body of earlier investigations has examined the role of oxidative stress in insulin resistance in type 1 and type 2 diabetes and its associated complications [2] . The investigations have revealed that hyperglycemia degrades antioxidant enzyme defenses by allowing reactive oxygen species to damage cells and tissues [3] . The balance of glucose by the drugs has emerged as a novel therapeutic approach to disease that develop with high circulating glucose.…”

Section: Introductionmentioning

confidence: 99%

Liken Ekstrelerinin Sağlıklı Ratlar Üzerindeki Etkileri ve Bu Ekstrelerin Diyabete Bağlı Çoklu Organ Yetmezliğinin Önlenmesinde Medikal Kullanımı

Çolak¹,

Geyikoğlu²,

Türkez³

et al. 2015

Kafkas Univ Vet Fak Derg

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In the present study, we firstly assessed Cetraria islandica and Pseudevernia furfuracae to avoid detrimental effects on multiple tissues of rats. Diabetes mellitus (DM) with the subsequent generation of oxidative stress represents a major risk factor for organs. The second aim of this study is to investigate whether administration of both lichens could prevent type 1 diabetes (T1D)-induced organ dysfunctions. During two weeks, both control and diabetic rats were treated with aqueous lichen extracts. The metabolic changes were determined. On day 14, after animals were decapitated, required samples for biochemical and genetic analysis were collected. Oxidative damage of DNA was estimated by measuring the increase in 8-hydroxy-2'-deoxyguanosine formation. Biochemical parameters were used to observe and evaluate the functional changes in tissues. Experimental data showed that the increasing doses of lichens alone have not any detrimental effect on above parameters. Moreover, C. islandica decreased the diabetes-induced glucose and malondialdehyde (MDA) levels. Thus, it seemed that the antioxidant treatment has an important effect on the organ failure in ill rats. However, the protective effect of C. islandica was inadequate on diabetesinduced disorders and DNA damages. Lichens are a safe in the studied dose range but the power of C. islandica is limited because of intensive oxidative stress in essential organs of T1D rats. Keywords: Cetraria islandica, Pseudevernia furfuracae, Diabetes mellitus, Organ dysfunctions, Antioxidant capacity, 8-hydroxy-2'-deoxyguanosine Liken Ekstrelerinin Sağlıklı Ratlar Üzerindeki Etkileri ve Bu Ekstrelerin Diyabete Bağlı Çoklu Organ Yetmezliğinin Önlenmesinde Medikal Kullanımı ÖzetBu çalışmada, ilk olarak Cetraria islandica ve Pseudevernia furfuracae türü liken ekstraktlarının sıçanlara ait çeşitli dokular üzerine zararlı etkilerinin olup olmadığı değerlendirilmiştir. Diabetes mellitusa (DM) bağlı oksidatif stres, organlar için büyük bir risk faktörü oluşturmaktadır. Çalışmamızın ikinci bölümünde ise her iki liken ekstaktı uygulamasının tip 1 diyabet kaynaklı organ bozukluklarına karşı koruyucu olup olmadıklarını araştırılmıştır. İki hafta boyunca hem kontrol hem de diyabetli ratlara sulu liken ekstreleri uygulanmıştır. Süre sonunda metabolik değişimler belirlenmiştir. Ondördüncü günde, hayvanların yaşamları servikal dislokasyonla sonlandırıldıktan sonra biyokimya ve genetik çalışmalar için gerekli örnekler alınmıştır. DNA'nın oksidatif hasarı 8-hidroksi-2'-deoksiguanosin oluşumunda meydana gelen artış ölçülerek hesaplanmıştır. Biyokimyasal parametreler dokularda meydana gelen fonksiyon değişimlerinin gözlenmesi ve değerlendirilmesi için kullanılmıştır. Deney sonuçları tek başına uygulanan liken ekstraktlarının artan dozlarda herhangi bir zararlı etkiye sahip olmadığını göstermiştir. Ayrıca, C. islandica diyabete bağlı artan kan glikoz ve malondialdehit (MDA) seviyesini kısmen düşürmüştür. Antioksidan tedavinin hasta ratlarda organ yetmezliğine karşı fayda sağlayacağı düşünülme...

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Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: Protective effect of 17β-estradiol

Cited by 66 publications

References 30 publications

Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

Mechanisms of Diabetes-Induced Liver Damage: The role of oxidative stress and inflammation

The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

Liken Ekstrelerinin Sağlıklı Ratlar Üzerindeki Etkileri ve Bu Ekstrelerin Diyabete Bağlı Çoklu Organ Yetmezliğinin Önlenmesinde Medikal Kullanımı

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