Hyperglycaemia in Rats after Diazinon and other Cholinesterase Inhibitors.

Dybing, Ottar; Søgnen, Erling

doi:10.1111/j.1600-0773.1958.tb01160.x

Cited by 18 publications

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“…It is well known that acute doses of organophosphorus compounds induce changes in blood sugar, blood lactic acid, and glycogen content in various tissues of laboratory mammals (Dybing & Sognen 1958;Murphy 1969;Gupta 1974). Chlorinated hydrocarbon insecticides induce a strong hypergly-caemic response in fish (Grant & Mehrle 1973;Silbergeld 1974) but effects of organophosphorus compounds on carbohydrate metabolism in fish has been only sparsely studied (Srivastava & Singh 1980).…”

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confidence: 99%

Effects of Acute Exposure to Methyl Parathion on Carbohydrate Metabolism of Indian Catfish (Heteropneustes fossilis)

Srivastava

Singh

1981

Acta Pharmacologica et Toxicologica

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Absrracr: Exposure of the Indian catfish (Hetefopneustes fossilis) to a high sublethal concentration of 5.6 p.p.m. (0.8 of the 96 hr LC50) of methyl parathion for 3,6,12,48, and 96 hrs affected carbohydrate metabolism. Muscle glycogen levels decreased significantly at 3,6,12 and 96 hrs; liver glycogen content declined at 6 hrs but there was a resynthesis of hepatic glycogen stores at 12 hrs. Blood glucose levels in fish were elevated at 3 and 6 hrs. Mean values for blood pyruvate were elevated significantly at 6,12, an'd 96 hrs. Blood lactate level was elevated at 3 hrs but hypolactaemia resulted at 48 and 96 hrs in pesticide-treated fish. The observed effects of methyl parathion on carbohydrate metabolism in fish are discussed in relation to acute stress syndrome. Measurement of carbohydrate metabolites in fish for 3 hrs or longer could prove useful as a rapid method for evaluating toxicity ofpesticides and other toxicants.

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Effects of Acute Exposure to Methyl Parathion on Carbohydrate Metabolism of Indian Catfish (Heteropneustes fossilis)

Srivastava

Singh

1981

Acta Pharmacologica et Toxicologica

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Changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals

Matin

Husain

1987

J of Applied Toxicology

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Effect of diazinon (10,20 and 40 mg/kg, i.p.) on the level of blood glucose in rats was investigated. Hyperglycaemia peaked 2 h after i.p. treatment with 40 mg/kg diazinon. The cerebral acetylcholinesterase activity was significantly reduced. The blood level of pyruvic acid was unchanged while that of lactic acid was significantly increased. Convulsions and biochemical changes caused by diazinon (40 mg/kg) were prevented by diazepam injected immediately after diazinon. In diazinon-treated hyperglycaemic animals, the glycogen content of the brain was depleted, the activities of glycogen phosphorylase, phosphoglucomutase and hexokinase were significantly increased and the activity of glucose-6-phosphatase remained unchanged. Lactate dehydrogenase activity was also increased by treatment with diazinon. The induced changes may compensate for the energy requirement of stimulatory effects caused by diazinon.

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Cerebral glucose and glycogen metabolism in diazinon‐treated animals

Matin

Husain

1987

J. Biochem. Toxicol.

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The intraperitoneal (IP) treatment of rats with diazinon (40 mg/kg) resulted in a variety of changes in the brain. Glycogen was depleted, but there was an increase in the activities of glycogen phosphorylase, phosphoglucomutase, hexokinase, lactate dehydrogenase, and fructose 1,6 diphosphatase. The activity of glucose-6-phosphatase was unaffected while that of cholinesterase was significantly reduced. Lactic acid content was increased, while that of pyruvate was not altered. Animals developed tremors and convulsions, which were maximal two hours after treatment. The induced changes may be compensatory mechanisms to provide extra energy to cerebral tissue as a result of the stimulatory effects in diazinon-treated animals.

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Hyperglycaemia in Rats after Diazinon and other Cholinesterase Inhibitors.

Cited by 18 publications

References 1 publication

Effects of Acute Exposure to Methyl Parathion on Carbohydrate Metabolism of Indian Catfish (Heteropneustes fossilis)

Effects of Acute Exposure to Methyl Parathion on Carbohydrate Metabolism of Indian Catfish (Heteropneustes fossilis)

Changes in cerebral glycogenolysis and related enzymes in diazinon treated hyperglycaemic animals

Cerebral glucose and glycogen metabolism in diazinon‐treated animals

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