Hyperglycaemia and Haemorrhagic Shock in Pregnancy

Murdoch, R.

doi:10.1111/j.1471-0528.1953.tb07278.x

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…Whiteley & Eglin, 1949;U.S. Army, 1952) and pregnant women (Murdoch, 1953), or to specific injuries, such as burns (Taylor, Levenson & Adams, 1944). Interest in the substrate and hormone changes after injury has now widened (Meguid, Brennan, Aoki, Muller, Ball & Moore, 1974;Smith, Fuller, Wedge, Williamson & Alberti, 1975; Batstone, Alberti, Hinks, Smythe, Laing, Ward, Ely & Bloom, 1976), and analytical methods have improved.…”

Section: Introductionmentioning

confidence: 94%

The Relationships between Plasma Substrates and Hormones and the Severity of Injury in 277 Recently Injured Patients

et al. 1979

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1. The plasma concentrations of glucose, lactate, amino acids, non-esterified fatty acids, glycerof, ketone bodies, ethanol, cortisol and insulin were measured in patients withii a few hours of injury and before treatment.' The severity of the injuries was assessed by the Injury Severity Score (ISS) method.2. Plasma lactate and glucose concentrations both rose significantly with increasing ISS.3. The concentrations of non-esterified fatty acids and glycerol were greater after moderate (ISS 7-12) than after minor (ISS 1-6) injuries. The glycerol concentrations were no higher and the non-esteritied fatty acid concentrations were lower after severe (ISS > 12) than after moderate injuries. The concentrations of total ketone bodies tended to follow those of non-esterified fatty acids and there was a highly significant correlation between them. 4. The total concentration of amino acids was not affected by the severity of injury and there were no systematic changes in the concentrations of individual ones. 5. Plasma insulin concentrations were very variable and not related to severity. A weak correlation with the plasma glucose concentration seen after minor and moderate injuries was lost in the severely injured. Correspondence: Professor H. B. Stoner, MRC Trauma Unit, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.6. The plasma cortisd concentration was positively related to ISS up to ISS 12 but negativeIy so in the severely injured.7. Factors such as age, sex and time after last meal were investigated. The most important factor modifying the response was intake of ethanol, which reduced the plasma concentrations of glucose, non-esterilied fatty acids and alanine and raised that of lactate as well as the hydroxybutyratel/LacetoacetateI ratio,

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Section: Introductionmentioning

confidence: 94%

The Relationships between Plasma Substrates and Hormones and the Severity of Injury in 277 Recently Injured Patients

et al. 1979

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“…It has been known since the time of Claude Bernard that haemorrhage and injury can cause hyperglycaemia. In man the size of this response can be fairly well correlated with the size of the injury be it due to burns (Taylor, Levenson and Adams, 1944), combat (Green et al, 1949) or obstetric haemorrhage (Murdoch, 1953). The correlation is less good in the postabsorptive rat (Ashby, Heath and Stoner, 1965;Heath and Corney, unpublished results), perhaps reflecting the different feeding pattern and smaller glycogen stores of the rat.…”

Section: Hyperglycaemiamentioning

confidence: 97%

The Effects of Trauma on Carbohydrate Metabolism

Stoner¹,

Heath²

1973

British Journal of Anaesthesia

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“…During the ebb phase the first sign, early observed, is hyperglycemia. The degree of hyperglycemia is rather well correlated to the severity of the trauma (TAYLOR et al 1944, GREEN et al 1949, MURDOCH 1953. The increase in blood glucose must be due to an elevated glucose output from the liver and/or to a decreased combustion of glucose peripherally.…”

Section: Hyperglycemiamentioning

confidence: 99%

Normal Carbohydrate Metabolism and Carbohydrate Metabolism in Trauma

Hultman

Bergström

Nilsson

1974

Acta Anaesthesiol Scand

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The great lability of man's glucose reserves as shown by the decreases in liver glycogen both during short starvation, decreased intake of carbohydrate or as an effect of trauma shows the importance of carbohydrate administration both in the normal man and in the treatment of trauma. Even if a relative intolerance to glucose is seen in the post-traumatic phase, it seems reasonable to use glucose possibly together with insulin its the basic calorie supply. The most important reason for this is that during hypoxia, which can readily occur, the only useful fuel is glucose transported via the blood or stored in the tissues as glycogen.

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Hyperglycaemia and Haemorrhagic Shock in Pregnancy

Abstract: BY 785

Cited by 6 publications

References 11 publications

The Relationships between Plasma Substrates and Hormones and the Severity of Injury in 277 Recently Injured Patients

The Relationships between Plasma Substrates and Hormones and the Severity of Injury in 277 Recently Injured Patients

The Effects of Trauma on Carbohydrate Metabolism

Normal Carbohydrate Metabolism and Carbohydrate Metabolism in Trauma

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