Large amounts of the rheumatoid factor were found in the serum of patients with far advanced, active rheumatoid disease, many of whom had "Feltys syndrome," and all of whom had subcutaneous nodules. A large part of the associated elevated gamma globulin was due to the abnormal 22 S rather than the 7 S component found in other diseases. Whether this 22 S component is but another manifestation of the disease or plays an active role in pathogenesis of various complications is not known at present.Grande quantitates de factor rheumatoide esseva trovate in le sero de patientes con avantiatissime morbo rheumatoide active, multes con "syndrome de Felty," omnes con nodulos subcutanee. Un grande portion del associate augment0 de globulina gamma representava le anormal componente 22 S plus tosto que le componente 7 S que es trovate in altere morbos. Si le componente 22 S es solmente un del manifestationes del morbo o si ill0 es un factor active in le pathogenese de varie complicationes remane un question aperte a iste tempore.