Hyperfractionation: where do we stand?

Biological Factors Influencing Optimum Fractionation in Radiation Therapy

“…In Fig. 5 the BED values are shown for the external beam dose (dashed curves) which is isoeffective for 5-year biochemical control with permanent I-125 implants prescribed to 145 Gy (full curves for three different values of T There is only slight evidence that this might be a real problem for tissues other than spinal cord or brain (34)(35)(36).…”

Hyperfractionated and accelerated-hyperfractionated radiotherapy for glioblastoma multiforme

“…Two recent reviews also concluded that to date there is no clear evidence for improved survival when escalating the dose of hyperfractionated or accelerated radiotherapy of malignant glioma [4,12].…”

Benefits of Accelerated Hyperfractionation for Head and Neck Cancer

“…A summary of that analysis is presented in Table 2, to which have been added the data from the PMH trial, analyzed in the same way. Other reviewers who expressed a contrary view considered that the evidence to support the use of hyperfractionation was inconsistent and that increases in late toxicity may offset any improvement in tumor control (24). We are of the opinion that there is merit to hyperfractionation.…”