1988
DOI: 10.1016/0360-3016(88)90085-5
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Hyperfractionation for head and neck cancer

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Cited by 156 publications
(30 citation statements)
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“…As a result, chemotherapy and radiotherapy often have been integrated employing split-course radiotherapy, where interruptions of all therapy, similar to the administration of chemotherapy in cycles, are introduced to allow for normal tissue recovery. This approach is controversial, since protraction of radiotherapy as a single-treatment modality has been shown to be detrimental [25][26][27][28]. However, the addition of chemotherapy to a split course of radiotherapy may at least compensate for the planned interruption of radiotherapy [29].…”
Section: Intermittent Schedule Of Chemoradiotherapymentioning
confidence: 99%
“…As a result, chemotherapy and radiotherapy often have been integrated employing split-course radiotherapy, where interruptions of all therapy, similar to the administration of chemotherapy in cycles, are introduced to allow for normal tissue recovery. This approach is controversial, since protraction of radiotherapy as a single-treatment modality has been shown to be detrimental [25][26][27][28]. However, the addition of chemotherapy to a split course of radiotherapy may at least compensate for the planned interruption of radiotherapy [29].…”
Section: Intermittent Schedule Of Chemoradiotherapymentioning
confidence: 99%
“…However these better treatment outcomes are associated with increased morbidity worsening quality of life of the patient [2][3][4][5][6][7][8][9][10][11][12][13][14]. HNC patients are more likely to experience nutritional deficiencies during all phases of disease [15][16][17][18][19][20][21][22][23].…”
Section: Introductionmentioning
confidence: 99%
“…Results have shown improved local-regional control with increase in dose with no increase in late toxicities. Parsons et al [15] estimated an approximate 15% increase in tumor control probability as compared to historical controls with their hyperfractionated schedules for moderately advanced to advanced primary squamous cell carcinomas of head and neck and without any overall increase in late complications. To further delineate whether or not there is a benefi t to hyperfractionation, the RTOG has recently completed a randomized study of hyperfractionation versus conventional fractionation in T 2 squamous cell carcinoma (SCC) of the vocal cord (RTOG 95-12/EORTC 22992).…”
Section: Altered Fractionationmentioning
confidence: 99%