Hyperfractionated total body irradiation for bone marrow transplantation: II. Physical aspects of the combined electron-photon treatment plan

Simpson, Larry D.; Reid, Ann; Hopfan, Seymour; Shank, Brenda; Finegan, Denise; Chui, Chen Shou; O’Reilly, Richard; Grossbard, Elliot; Kapoor, Neena; Dinsmore, Robert E.; Kirkpatrick, Dahlia; Kim, J.; Chug, F.

doi:10.1016/0360-3016(80)90471-x

International Journal of Radiation Oncology*Biology*Physics

1980

DOI: 10.1016/0360-3016(80)90471-x

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Hyperfractionated total body irradiation for bone marrow transplantation: II. Physical aspects of the combined electron-photon treatment plan

Larry D. Simpson¹,

Ann Reid²,

Seymour Hopfan³

et al.

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1981

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Fractionated total body irradiation and high dose cyclophosphamide: a preparative regimen for bone marrow transplantation for patients with hematologic malignancies in first complete remission

Snyder

Findley

Forman

et al. 1988

Blut

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We treated 73 patients with hematologic malignancies in first complete remission (acute lymphoblastic leukemia = 23 patients; acute non-lymphoblastic leukemia = 25 patients; chronic myelogenous leukemia in first chronic phase = 20 patients, and high grade lymphoma = five patients) with a uniform preparative regimen consisting of fractionated total body irradiation (1,320 cGy) and high dose cyclophosphamide (100 mg/kg), followed by allogeneic bone marrow transplantation. By radiation dosimetry we demonstrated that the calculated doses were delivered accurately and reproducibly. Actuarial survival rates (+/- SEM) in complete remission were as follows: Acute lymphoblastic leukemia = 74 +/- 9%; acute nonlymphoblastic leukemia = 50 +/- 11%; and chronic myelogenous leukemia = 55 +/- 11%. Actuarial relapse rates for these three diagnoses were 19 +/- 9%, 17 +/- 11%, and 0% respectively. Three of the five lymphoma patients are alive in complete remission at 22+, 28+, and 54+ months. Overall probability of survival for the 73 patients was 59 +/- 7%. Interstitial pneumonia, usually associated with cytomegalovirus infection and graft-versus-host disease, and relapse of the underlying malignancy were the major causes of death.

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Fractionated total body irradiation and high dose cyclophosphamide: a preparative regimen for bone marrow transplantation for patients with hematologic malignancies in first complete remission

Snyder

Findley

Forman

et al. 1988

Blut

View full text Add to dashboard Cite

show abstract

Hyperfractionated total body irradiation for bone marrow transplantation: I. early results in leukemia patients

Shank

Hopfan

Kim

et al. 1981

International Journal of Radiation Oncology*Biology*Physics

120

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Techniques of magna-field irradiation

Shank

1983

International Journal of Radiation Oncology*Biology*Physics

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Hyperfractionated total body irradiation for bone marrow transplantation: II. Physical aspects of the combined electron-photon treatment plan

Cited by 6 publications

References 0 publications

Fractionated total body irradiation and high dose cyclophosphamide: a preparative regimen for bone marrow transplantation for patients with hematologic malignancies in first complete remission

Fractionated total body irradiation and high dose cyclophosphamide: a preparative regimen for bone marrow transplantation for patients with hematologic malignancies in first complete remission

Hyperfractionated total body irradiation for bone marrow transplantation: I. early results in leukemia patients

Techniques of magna-field irradiation

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