Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis

Bourhis, Jean; Overgaard, Jens; Audry, Hélène; Ang, K. Kian; Saunders, M.I.; Bernier, Jacques; Horiot, Jean-Claude; Maître, Aurélie Le; Pajak, Thomas F.; Poulsen, Michael; O’Sullivan, Brian; Dobrowsky, W.; Hliniak, A; Składowski, Krzysztof; Hay, John; Pinto, Luiz H. J.; Fallai, C.; Fu, Karen K.; Sylvester, Richard; Pignon, Jean-Pierre

doi:10.1016/s0140-6736(06)69121-6

Cited by 959 publications

(532 citation statements)

References 23 publications

Supporting

Mentioning

505

Contrasting

Unclassified

Order By: Relevance

“…However, as far as the simple assumption mentioned earlier holds, the present study can provide us with a criterion for the validity of the hypofraction or the multi-fractionation regimen as Eqs. (1) and (2).…”

Section: Resultsmentioning

confidence: 99%

“…varying the number of fractions or dose per fraction for various tumor sites and types in actual clinical cases. The effectiveness of hyperfractionated, hypofractionated, or accelerated radiotherapy has been investigated in head and neck cancer (2,3) and breast cancer (4). Continuous hyperfractionated accelerated radiotherapy (CHART) was introduced in the 1980s.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear–Quadratic Model

Mizuta

Sugiyama

Date

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

104

View full text Add to dashboard Cite

Mizuta 2 AbstractPurpose: Hypofractionated irradiation is often used in precise radiotherapy instead of conventional multi-fractionated irradiation. We propose a novel mathematical method for selecting a hypofractionated or multi-fractionated irradiation regime based on physical dose distribution adding to biological consideration.Methods and Materials: The linear quadratic (LQ) model was employed for the radiation effects on tumor and normal tissues, especially OARs. Based on the assumption that the OAR receives a fraction of the dose intended for the tumor, the minimization problem for the damage effect on the OAR was treated under the constraint that the radiation effect on the tumor is fixed.Results: For an N-time fractionated irradiation regime, the constraint of tumor lethality was described by an N-dimensional hypersphere. The total dose of the fractionated irradiations was considered for minimizing the damage effect on the OAR under the hypersphere condition. It was found that the advantage of hypofractionated or multi-fractionated irradiation therapies depends on the magnitude of the ratio of  parameters for the OAR and the tumor in the LQ model and the ratio of the dose for the OAR and the tumor.Conclusions: The present mathematical method shows that the multi-fractionated irradiation Mizuta 3 with a constant dose is better if the ratio of  for the OAR and the tumor is less than the ratio of the dose for the OAR and the tumor, while hypofractionated irradiation is better otherwise.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear–Quadratic Model

Mizuta

Sugiyama

Date

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

104

View full text Add to dashboard Cite

show abstract

“…Treatment intensification with altered fractionation radiotherapy (AFRT) for head and neck cancer (HNC) has demonstrated improved locoregional control and overall survival compared with conventionally fractionated radiotherapy (1). Despite this benefit, AFRT treatment has been associated with increased acute toxicity of greater severity and longer duration (2,3).…”

Section: Introductionmentioning

confidence: 99%

Long-term Functional Outcomes and Patient Perspective Following Altered Fractionation Radiotherapy with Concomitant Boost for Oropharyngeal Cancer

et al. 2012

View full text Add to dashboard Cite

show abstract

“…8 Results similar to standard RT fractionation or better have been obtained with hypofractionated protocols. 3,[9][10][11][12][13] Both methods of altered fractionation have been shown to offer some advantages.…”

Section: Introductionmentioning

confidence: 76%

Hypofractionated accelerated radiotherapy in T1–3 N0 cancer of the larynx: A prospective cohort study with historical controls

Szutkowski

Kawecki

Jarząbski

et al. 2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis

Cited by 959 publications

References 23 publications

A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear–Quadratic Model

A Mathematical Study to Select Fractionation Regimen Based on Physical Dose Distribution and the Linear–Quadratic Model

Long-term Functional Outcomes and Patient Perspective Following Altered Fractionation Radiotherapy with Concomitant Boost for Oropharyngeal Cancer

Hypofractionated accelerated radiotherapy in T1–3 N0 cancer of the larynx: A prospective cohort study with historical controls

Contact Info

Product

Resources

About