Hyperfractionated 192Ir Brachytherapy for Recurrent Retroperitoneal Sarcoma: a Technique for Delivery of Local Tumor Boost Dose

Abstract

HFIR via intraoperatively implanted catheters in the retroperitoneum is a technique suitable for application of a local tumor boost dose. Thus, sufficiently high doses of radiation mandatory for long-lasting local tumor control can be delivered in the tumor bed of the retroperitoneum without exceeding normal tissue radiotolerance in this unfavorable disease.

Intraoperative Radiotherapy of Soft Tissue Sarcoma of the Extremity

“…For an optimal dose distribution, close contact of the flab with the tumor bed was mandatory with regard to the steep dose fall-off. This technique is different from intraoperatively placed plastic catheters which are loaded postoperatively [4]. After 1993, IORT was applied in part with a linear accelerator (Siemens Mevatron) using 8-to 10-MeV electrons, installed in a special operating room (twelve patients).…”

High-Dose-Rate (HDR) or Pulsed-Dose-Rate (PDR) Perioperative Interstitial Intensity-Modulated Brachytherapy (IMBT) for Local Recurrences of Previously Irradiated Breast or Thoracic Wall Following Breast Cancer

“…CT-based individual brachytherapy planning has been currently accepted for geometric optimization and realization of dose homogeneity for interstitial brachytherapy [11,13]. There are also reports in the literature on the use of interstitial brachytherapy as a treatment option for local recurrence of other tumors [3,10,26].…”

CT-gesteuerte Brachytherapie

“…Für die eigene Studie nehmen wir an, dass der Einsatz dreidimensionaler CT-Datensätze und die damit verbundene hohe Genauigkeit der Dosimetrie entscheidend für die guten Resultate hinsichtlich lokaler Tumorkontrolle gewesen sind [2,14,15,21,23,27]. Die Schnittbildführung im Rahmen der Applikatoreinbringung bei interstitieller Brachytherapie von Lebermalignomen wurde bereits durch Kettenbach et al [12] diskutiert.…”