Hyperfibrinogenemia: A Novel Predictor to Identify the Necrotizing Enterocolitis in Newborn Infants

Abstract

Necrotizing enterocolitis (NEC) is one of the most common devastating gastrointestinal emergencies and affect premature intestine infants. However, there is still a lack of indications for timely surgery, which cause complications and miss the optimal surgical timing. We collected plasma fibrinogen from 168 postoperative NEC patients using the pt-der method and the patients were divided into four groups, including 68 Infant patients with intestinal perforation and necrosis (IPN), 61 Infant patients of intestinal necrosis without perforation (INWP), 15 Infant patients of intestinal perforation without necrosis (IPWN), and 24 infants without necrosis and perforation (WNP). Compared to no intestinal necrosis patients, there was a significant increase of the fibrinogen level in NEC children with intestinal necrosis. This study may provide important information for early diagnosis of infant patients with intestinal necrosis for immediate decision of surgery.