Hypereosinophilic syndrome with unusual cutaneous manifestations in two men with HIV infection

May, Lewis Pete; Kelly, Joan; Sanchez, Miguel

doi:10.1016/0190-9622(90)70199-r

Cited by 39 publications

(22 citation statements)

References 8 publications

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“…[21] Hypereosinophilic syndrome May et al, have described two men with HIV infection who had unusual cutaneous manifestations of hypereosinophilic syndrome, exfoliative erythroderma and linear flagellate plaques. [24] Chikungunya fever induced fl agellate pigmentation Chikungunya fever commonly causes hyperpigmentation such as accentuation of melasma, pigmentation of nose, periorbital melanosis and irregular and flagellate patterns on the trunk and extremities. It is primarily considered a post-inflammatory response with the chikungunya virus probably triggering intraepidermal melanin dispersion or retention.…”

Section: Chemotherapy Induced Fl Agellate Dermatitis and Pigmentationmentioning

confidence: 99%

Flagellate dermatoses

Bhushan¹,

Manjul²,

Baliyan³

2014

Indian J Dermatol Venereol Leprol

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Section: Chemotherapy Induced Fl Agellate Dermatitis and Pigmentationmentioning

confidence: 99%

Flagellate dermatoses

Bhushan¹,

Manjul²,

Baliyan³

2014

Indian J Dermatol Venereol Leprol

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“…May and colleagues reported two cases of a predominantly cutaneous hypereosinophilic syndrome in HIVinfected patients with advanced disease (6). We present an additional case of this entity in whom IL-5, a cytokine which regulates eosinophil production, was found to be elevated during the eruption but was not in prior or subsequent samplings.…”

Section: Supplementary Notesmentioning

confidence: 74%

Hypereosinophilic Syndrome Associated With HIV Infection

Magill¹,

Smith²,

Nutman³

et al. 1994

Southern Medical Journal

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“…10,12,[18][19][20] There is also a shift from R5 to more pathogenic X4 strains of HIV-1 74-77 and from a Th1 to less protective Th2 cytokine profile 34,78,79 in a significant portion of AIDS patients. Interleukin 5, one of the Th2 cytokines, promotes the differentiation of eosinophils from the bone marrow 4,80 and could explain the eosinophilia documented in AIDS patients.…”

Section: Discussionmentioning

confidence: 99%

“…5 Furthermore, many HIV-infected individuals develop hypereosinophilia concomitant with the progression of clinically latent HIV infection to AIDS. [10][11][12][13][14][15][16][17][18][19][20] Eosinophil counts can be as high as eight times the normal level in these individuals, approaching 50% in HIV-1infected individuals; normal counts are 2-5%. 10,12,[18][19][20] Absolute numbers, as well as proportions, of eosinophils in the blood are also higher in AIDS patients as compared with casematched controls.…”

Section: Introductionmentioning

confidence: 99%

Restricted Entry of R5 HIV Type 1 Strains into Eosinophilic Cells

Taylor

Schols

Wooley

2004

AIDS Research and Human Retroviruses

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A cell culture system previously developed by our laboratory demonstrated that T cell-tropic (CXCR4-using) but not macrophage-tropic (CCR5-using) HIV-1 strains productively infected eosinophilic cells. In the current study, an improved model was used to determine the level of this viral restriction by assessing viral entry and coreceptor usage. The model was improved by using AML14.3D10 cells that were engineered to express CCR3 in addition to the major HIV-1 coreceptors, CD4, CXCR4, and CCR5, thus making them more like primary eosinophils. A polymerase chain reaction (PCR) assay was used to detect viral entry. In the PCR assay, primers specific for early reverse transcription products were used to amplify minus strand viral DNA from HIV-1-infected AML14.3D10-CCR3 eosinophilic cells. Coreceptor blocking experiments, using the CXCR4 antagonist AMD3100, were performed to determine coreceptor usage by the CXCR4-using (X4) strain known to productively infect the cells. Virus production was measured by p24 immunoassay. As expected, viral DNA was detected in AML14.3D10-CCR3 cells infected with X4 HIV-1, and cell viability was decreased during maximal viral production. Conversely, viral DNA was not detected in eosinophilic cells exposed to a CCR5-using (R5) HIV-1 strain that is also capable of using CCR3, indicating that R5 HIV-1 is unable to enter eosinophilic cells despite the presence of the appropriate coreceptors. Infection of AML14.3D10-CCR3 cells by HTLV-III(B) was completely inhibited by AMD3100, indicating that X4 HIV-1 enters the AML14.3D10-CCR3 cell line by using the CXCR4 coreceptor exclusively. Since X4 strains predominate during the late stages of HIV-1 infection in many patients, when eosinophil numbers also tend to increase, the ability of these HIV-1 strains to infect eosinophilic cells has important implications for the involvement of eosinophils in the pathogenesis of AIDS.

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Hypereosinophilic syndrome with unusual cutaneous manifestations in two men with HIV infection

Cited by 39 publications

References 8 publications

Flagellate dermatoses

Flagellate dermatoses

Hypereosinophilic Syndrome Associated With HIV Infection

Restricted Entry of R5 HIV Type 1 Strains into Eosinophilic Cells

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