Hypereosinophilic syndrome with Loeffler endocarditis

Abstract

Introduction: Hypereosinophilic syndromes (HES) are a group of multisystemic disorders marked by a sustained overproduction of eosinophils, in which eosinophilic infiltration and mediator release cause damage to multiple organs. 1 Cardiac involvement is present in 40% of cases and is one of the most serious manifestations of HES, accounting for approximately one-half of deaths. 2 We report a case of Loeffler endocarditis detected by echocardiography.Case report: 68-year-old male presented with symptoms of behavioural changes. The patient was diagnosed with rheumatic polimyalgia two years ago and treated with low-dose prednisolon. Development of eosinophilic granulomatosis with polyangiitis (EGPA) has been suspected. Magnetic resonance imaging of the brain revealed multiple ischemic lesions. Two-dimensional transthoracic echocardiography (TTE) showed a normally sized left ventricle with normal systolic function without regional wall motion abnormalities and no signs of diastolic disfunction. The valves showed no significant pathology. An echodense structure that obliterated the left ventricular apex was detected, consistent with thrombus (Figure 1). The formation was further investigated with administration of contrast (Sonovue) and three-dimensional TTE and transesophageal echocardiography. Loeffler endocarditis with apical thrombus was suspected with distant embolization to the central nervous system. Highdose prednisolone therapy in combination with pulsed cyclophosphamide regimen was started and anticoagulation therapy with warfarin was instituted. The symptoms began to resolve and the patient reports no further manifestations of the disease. Serial monthly follow-up TTE exams demonstrate apical thrombus regression and no further cardiac involvement so far.