Hypereosinophilic Syndrome Associated with Simultaneous Intracardiac Thrombi, Cerebral Thromboembolism and Pulmonary Embolism

Büyüktaş, Deram; Eşkazan, Ahmet Emre; Börekçi, Şermin; Umut, Sema; Öngen, Zeki; Tuzuner, Nukhet; Soysal, Teoman

doi:10.2169/internalmedicine.51.6156

Cited by 9 publications

(8 citation statements)

References 10 publications

(10 reference statements)

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“…In some reports regarding HES patients, neither warfarin nor heparin avoided fatal outcome once thrombosis had occurred, [8] but there are some successful cases with LMWH. [4,25] Though the standard care of DVT is LMWH followed by a vitamin K antagonist, in our case we initially chose a Factor Xa inhibitor, rivaroxaban, in the setting of thrombocytopenia and suspected DIC, since some literatures indicate that a Factor Xa inhibitor may cause fewer major bleeding events than warfarin or LMWH. [26–28] After the use of steroid and rivaroxaban, the patient's EO followed with platelet count recovered and the swollen extremity progressively improved, but the fibrinogen level remained low.…”

Section: Discussionmentioning

confidence: 99%

Hypereosinophilic syndrome presenting with multiple organ infiltration and deep venous thrombosis

et al. 2016

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Background:Hypereosinophilic syndrome (HES) can be fatal, particularly when eosinophils infiltrate vital organs and/or if extensive thrombosis develops. However there are no standard recommendations for the use of anticoagulant therapy of HES in the setting of thrombosis.Methods:We herein present a case of a 46-year-old female who presented with marked peripheral eosinophilia with symptoms of multi-organ infiltration and extensive deep venous thrombosis (DVT). In this case, evaluation was carried out before the diagnosis was established, and timely standard-dose corticosteroids combined with a new oral anticoagulant (NOAC) therapy were carried out.Results:These measures resulted in a rapid response and long-term disease control.Conclusion:Although there are no data to support which anticoagulant is preferred in this setting, this case indicates that the new oral anticoagulants may play an important role in the treatment of thrombosis in HES.

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Section: Discussionmentioning

confidence: 99%

Hypereosinophilic syndrome presenting with multiple organ infiltration and deep venous thrombosis

et al. 2016

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“…In HES, recurrence of thrombosis even after reduced eosinophilia may be due to residual endothelial damage from prolonged eosinophilia, warfarin failure, or potentially eosinophilindependent mechanisms (Leon-Ferre et al 2013). The chronic suppressive treatment for eosinophilia should not be interrupted due to the risk of new thromboembolic events which can be life-threatening (Buyuktas et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Hypereosinophilic Syndrome with Unusual Presentation: Two Case Reports And Review of Literature

Aziz¹

2018

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“… 1 Occasionally, LV thrombus can be found in patients with hypertrophic cardiomyopathy and hypereosinophilia. 14 , 15 It is often accompanied by peripheral vascular thromboembolic complications such as stroke, and thus has a high mortality and morbidity. 2 – 3 , 13 LV thrombi may be significantly reduced or even completely dissolved if timely and effective anticoagulant and/or antithrombotic therapy is administered.…”

Section: Discussionmentioning

confidence: 99%

Application of spectral computed tomography dual-substance separation technology for diagnosing left ventricular thrombus

Zeng

Zhang

et al. 2015

J Int Med Res

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ObjectiveTo investigate the value of spectral computed tomography (CT) dual-substance separation technology for diagnosing left ventricular (LV) thrombus.MethodsIn this observational case–control study, spectral CT scans were conducted in patients with and without LV thrombi. Densities in the regions of the LV cavity, papillary muscles and LV thrombus were observed on 140kVp mixed-energy and 70 keV single-energy images. Iodine and blood were chosen as the base material pair, the densities were observed and the iodine and blood concentrations were quantitatively measured.ResultsA total of 24 patients were enrolled in this study. On iodine-based density images, both the LV thrombus and papillary muscles showed low-attenuation shadows. On blood-based density images, comparable high-density attenuation was found in the LV thrombus and LV cavity, while relative hypodensity was noted in the papillary muscles. Iodine and blood densities were significantly lower in papillary muscles than in the LV cavity. Iodine densities were significantly lower in the LV thrombus than the LV cavity, whereas blood densities in the two areas did not differ significantly.ConclusionsSpectral CT dual-substance separation technology and its derived images of iodine- and blood- based densities provide a new, simple, and feasible semiquantitative method to detect LV thrombus that warrants further investigation.

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Hypereosinophilic Syndrome Associated with Simultaneous Intracardiac Thrombi, Cerebral Thromboembolism and Pulmonary Embolism

Cited by 9 publications

References 10 publications

Hypereosinophilic syndrome presenting with multiple organ infiltration and deep venous thrombosis

Hypereosinophilic syndrome presenting with multiple organ infiltration and deep venous thrombosis

Idiopathic Hypereosinophilic Syndrome with Unusual Presentation: Two Case Reports And Review of Literature

Application of spectral computed tomography dual-substance separation technology for diagnosing left ventricular thrombus

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