Hypereosinophilia Associated with Increased Serum Levels of Carcinoembryonic Antigen

Iwata, Hiroka; Tsuboi, Nobuyuki; Ishii, Takeo; Hara, Yoichiro; Okido, Ichiro; Takahashi, Hajime; Kawamura, Tetsuya; Hosoya, Tatsuo

doi:10.2169/internalmedicine.47.0611

Cited by 6 publications

(6 citation statements)

References 15 publications

(8 reference statements)

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“…Additionally, clinical conditions that might result in false elevation should be considered in the preanalytical phase. These clinical conditions include smoking, hypothyroidism, hypereosinophilia, inflammatory bowel disease, and diabetes . Among those clinical conditions that might affect the level of CEA, diabetes is the most common chronic and metabolic disease.…”

Section: Introductionmentioning

confidence: 99%

HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals

Chung

Lee

Roh

2019

Clinical Laboratory Analysis

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Background This study was conducted to investigate the association of carcinoembryonic antigen (CEA) and glycated hemoglobin (HbA1c) in normal, prediabetic, and diabetic subjects. Methods A total of 2,911 participants who underwent general health checkups were enrolled and categorized into the normal, prediabetes, and diabetes groups. Demographic, anthropological, and clinical variables were investigated, and correlations with CEA were analyzed. For 28 diabetic subjects with CEA levels above the upper limit, the follow‐up CEA and HbA1c data were analyzed. Results Carcinoembryonic antigen levels were significantly different among the normal, prediabetes, and diabetes groups (1.7 ± 1.1 vs 2.0 ± 1.1 vs 2.5 ± 1.5; P < 0.001), and men had higher CEA levels than women in all three groups. Correlation analysis identified a significant positive correlation between serum CEA and HbA1c in the diabetes group using unadjusted and adjusted models (r = 0.189, P < 0.001 and r = 0.218, P < 0.001), and multiple linear regression analysis also revealed that HbA1c was independently and positively correlated with CEA in the diabetes group (β = 0.275, P < 0.001). However, these relationships were inconsistent in the normal and prediabetes groups. The changes in CEA and HbA1c from baseline to follow‐up (delta CEA and delta HbA1c) showed a significant positive correlation (P = 0.021). Conclusions In diabetes, the CEA level was independently and positively correlated with glycemic control status. Additionally, the change in CEA level (delta CEA) showed a positive correlation with the change in HbA1c level (delta HbA1c) in the follow‐up data analysis.

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Section: Introductionmentioning

confidence: 99%

HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals

Chung

Lee

Roh

2019

Clinical Laboratory Analysis

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“… 25 In certain allergic conditions, an increase in EOS count often coincides with elevated CEA levels, thereby serving as an indicator of disease progression. 8 – 13 However, the origin of elevated CEA in allergic diseases remains unclear. In this study, the asthmatic patients with hypereosinophilia and elevated serum CEA levels were thoroughly ruled out for potential causes related to infections, tumors, autoimmune disorders, and monoclonal gammopathy.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“… 5 – 7 Interestingly, in some rare cases, serum CEA levels have been found to reflect the progression of allergic respiratory diseases. 8 – 13 …”

Section: Introductionmentioning

confidence: 99%

Allergic hyper-carcinoembryonic antigen syndrome: A syndrome summarized by case series

Li,

Hong,

et al. 2024

SAGE Open Medical Case Reports

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Allergic respiratory diseases can increase serum carcinoembryonic antigen levels. We report three cases experiencing allergic symptoms that proved refractory to inhaled corticosteroids but exhibited a positive response to long-term treatment with oral corticosteroids. This response was characterized by a synchronous alteration in serum eosinophil counts and carcinoembryonic antigen levels. Immunofluorescence assays indicated localized carcinoembryonic antigen production within eosinophils. In addition, we conducted a systematic review of patients exhibiting similar characteristics on PubMed. After comprehensively reviewing this unique pathophysiological condition, we herein introduced a novel term “Allergic hyper-carcinoembryonic antigen syndrome,” defined by the following criteria: (1) recurrent asthmatic attacks; (2) eosinophilia or pulmonary eosinophilic infiltrations accompanied by elevated serum carcinoembryonic antigen levels; (3) pulmonary lesions determined by imaging or biopsy; (4) exclusion of malignancy and infections; and (5) responsive to systemic corticosteroids. Allergic hyper-carcinoembryonic antigen syndrome suggests systemic corticosteroids should be introduced early when managing allergic patients with both eosinophilia and elevated serum carcinoembryonic antigen levels.

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“…Serum CEA levels are increased in patients with lung, gastric, colorectal, pancreatic, and breast cancers. Increased serum levels of CEA in patients with hypereosinophilia and/or various eosinophilic lung diseases have been reported (8)(9)(10)(11). Serum CEA levels were elevated in a patient with eosinophilic bronchiolitis and sinusitis with overexpression of CEA in the lung and sinus.…”

Section: Adjuvant Chemotherapymentioning

confidence: 99%

Allergic Bronchopulmonary Mycosis Complicated with Lung Adenocarcinoma

et al. 2022

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Chest computed tomography (CT) of a 76-year-old woman with bronchial asthma showed multiple lung nodules with high CT densities that were compatible with high-attenuation mucoid (HAM) impactions characteristic of allergic bronchopulmonary mycosis (ABPM). Follow-up chest CT revealed increased sizes of multiple lung nodules. However, a left upper lobe nodule showed lower CT density than the other HAM impactions. A transbronchial lung biopsy of that upper lobe nodule revealed lung adenocarcinoma. Measuring the CT density is important for the differential diagnosis of lung nodules when following ABPM patients. Our patient's increased serum carcinoembryonic antigen levels were associated with peripheral blood eosinophilia. Mucoid impaction in the lung was positively stained with carcinoembryonic antigen and showed the distribution of eosinophilic granules.

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Hypereosinophilia Associated with Increased Serum Levels of Carcinoembryonic Antigen

Abstract: We report a case of hypereosinophilia associated with increased serum levels of carcinoembryonic antigen (CEA)

Cited by 6 publications

References 15 publications

HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals

HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals

Allergic hyper-carcinoembryonic antigen syndrome: A syndrome summarized by case series

Allergic Bronchopulmonary Mycosis Complicated with Lung Adenocarcinoma

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