Hypereosinophilia as a paraneoplastic phenomenon in non-small cell lung carcinoma

Nqwata, Lamla; Wong, Michelle; Mohanlal, Reena Dhansukh; Lakha, Atul

doi:10.7196/sarj.2015.v21i4.38

Cited by 6 publications

(8 citation statements)

References 4 publications

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“…Sometimes a combination of steroids and hydroxyurea can increase the response rate [ 6 ]. However, the cornerstone of management includes treating the malignancy by either chemotherapy or surgery [ 4 , 9 ]. It is worth mentioning that the presence of paraneoplastic eosinophilia is associated with a poor prognosis and a more aggressive tumor [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Eosinophilia is defined as an absolute eosinophil count (AEC) of more than 500 cells/µL. Hypereosinophilia is a more severe condition and is defined as having an AEC greater than 1500 cells/µL, without organ damage [ 2 - 4 ]. There are many causes of eosinophilia which include parasitic infections, allergic diseases, rheumatologic diseases, and neoplasms.…”

Section: Introductionmentioning

confidence: 99%

“…The cause of eosinophilia in solid malignancies is thought to be related to bone marrow stimulation through cytokines such as interleukin-5 (IL-5) [ 5 ]. There is no specific treatment for paraneoplastic eosinophilia other than treating the underlying malignancy [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Metastatic Lung Adenocarcinoma Presenting with Hypereosinophilia

Abughanimeh

Tahboub

Ghanimeh

2018

Cureus

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Lung cancer is one of the most common malignancies in both male and female patients. It is classified into small cell lung cancers and non-small cell lung cancers. Lung adenocarcinoma is a subtype of non-small cell lung cancer and accounts for the highest prevalence of lung cancer. Eosinophils are white blood cells (WBCs) that originate from the granulocytic lineage. Hypereosinophilia is a rare condition characterized by an absolute eosinophil count (AEC) of more than 1500 cells/µL. This is different from eosinophilia, which is defined as an absolute eosinophil count of more than 500 cells/µL. Hypereosinophilia is associated with several conditions, including allergic disorders, helminth infections, rheumatologic disorders, and hematologic malignancies. Paraneoplastic eosinophilia is a rare finding in solid malignancies. Herein, we report the case of a 55-year-old male who presented with shortness of breath and chest pain and whose workup showed metastatic lung adenocarcinoma associated with hypereosinophilia in the absence of a primary bone marrow disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metastatic Lung Adenocarcinoma Presenting with Hypereosinophilia

Abughanimeh

Tahboub

Ghanimeh

2018

Cureus

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“…Among the one hundred previously reported and analyzed by us cases of TABE, the death of 68 patients was reported ( 4 , 7 , 8 , 10 – 14 , 16 – 22 , 24 – 28 , 30 , 32 , 34 – 37 , 39 , 44 , 46 – 51 , 53 – 60 , 65 , 67 – 69 , 71 , 72 , 74 – 76 , 82 – 88 , 94 – 96 ). About 90% of the deaths occurred within one year after the diagnosis of paraneoplastic hypereosinophilia.…”

Section: Discussionmentioning

confidence: 99%

Hypereosinophilia in Solid Tumors—Case Report and Clinical Review

2021

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BackgroundRenal cell cancer may cause various paraneoplastic syndromes; however, paraneoplastic hypereosinophilia occurs exceedingly rare. Thus far, only two cases of clear cell renal cell carcinoma (CCRCC) associated with hypereosinophilia have been reported. In this paper, we present a case of paraneoplastic hypereosinophilia associated with renal cell carcinoma and a review of the reported cases of hypereosinophilia in solid tumors.MethodsThe review is based on an electronic literature search performed in the PubMed database in September 2020 with the following key terms: eosinophilia & neoplasm; eosinophilia & cancer; eosinophilia & paraneoplastic syndrome. Papers were included based on screening the titles and/or abstracts. We also included the case of our patient in the analysis.Case presentationA 68-year-old Caucasian female patient with recurrent CCRCC was admitted to our Clinic for exacerbating dyspnea and chest and right upper abdominal pain, accompanied by confusion. Preliminary blood tests showed an increased white blood cell count of 40,770/μl, and an increased eosinophil count of 6,530/μl indicating eosinophilia. Several tests were carried out to rule out the noncancer causes of hypereosinophilia. The temporal appearance of eosinophilia and the recurrence of CCRCC without any other apparent potential causes led to the diagnosis of paraneoplastic hypereosinophilia. Despite treating with high doses of corticosteroids, only a transient decrement in eosinophil count was observed along with further deterioration of the patient’s condition. The patient succumbed to the disease 6 months following the tumor surgery and 2 months after the diagnosis of hypereosinophilia and tumor recurrence.ConclusionOur observations are in agreement with the majority of reports showing that the occurrence of eosinophilia following tumor resection may indicate a poor prognosis, tumor recurrence, and rapid disease progression.

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“…It has been associated with a better prognosis in certain types of cancers like colorectal and esophageal squamous cell carcinoma, but with a poor outcome in patients with Hodgkin's lymphoma. 1 Concerning lung cancer, 3,4 and specifically nonsmall cell lung cancer (NSCLC), with the most common sub-type being lung adenocarcinoma, 2 hyper-eosinophilia has been consistently associated with extensive metastasis, poor response to therapy and overall a worse prognosis, particularly when a paraneoplastic process is functioning as the cause. 3 Pembrolizumab, one of the immune checkpoint inhibitors (ICI) used in the treatment of lung cancer, have recently revolutionized treatment in oncology, showing evidence of improved survival compared to conventional platinum-based chemotherapy in lung malignancy.…”

Section: Introductionmentioning

confidence: 99%

Lung Adenocarcinoma with Paraneoplastic Hyper-Eosinophilia Not Responding To Pembrolizumab

Wehbe

Kozah

Koubaissi

2021

Clin Med Insights Circ Respir Pulm Med

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Background: Paraneoplastic hyper-eosinophilia associated with metastatic lung adenocarcinoma is a rare finding and has been associated with a poor prognosis when present. Early hyper-eosinophilia appearing following non-small cell lung cancer (NSCLC) treatment with immune checkpoint inhibitors (ICI) has been previously reported with contradictory outcomes. Case summary: We present the case of an elderly man with newly diagnosed metastatic lung adenocarcinoma and baseline hyper-eosinophilia, treated with pembrolizumab, and showing evidence of significant and rapid disease progression suggestive of hyper-progressive disease, worsening baseline hyper-eosinophilia, and a fatal outcome within 1 month of therapy initiation. Conclusion: Pre-treatment hyper-eosinophilia could represent a predictive factor of an unfavorable response to ICI treatment in cases of NSCLC. Additional similar cases are needed to draw a more conclusive relationship.

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Hypereosinophilia as a paraneoplastic phenomenon in non-small cell lung carcinoma

Cited by 6 publications

References 4 publications

Metastatic Lung Adenocarcinoma Presenting with Hypereosinophilia

Metastatic Lung Adenocarcinoma Presenting with Hypereosinophilia

Hypereosinophilia in Solid Tumors—Case Report and Clinical Review

Lung Adenocarcinoma with Paraneoplastic Hyper-Eosinophilia Not Responding To Pembrolizumab

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