Hyperemic Response for Accurate Diagnosis of Arterial Insufficiency

Water, Joseph M. Van De; Indech, Christine D. V.; Indech, Robert B.; Randall, Henry T.

doi:10.1001/archsurg.1980.01380070039008

Cited by 11 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Propagating the ROI through the 120-image data set resulted in a plot of mean signal intensity (SI), averaged over the ROI, as a function of time. The mean SI at each time-point was then normalized to the mean signal intensity of the first 20 baseline images: SI normalized ϭ SI i /mean SI [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] (SI i ϭ mean SI, averaged over the ROI, at a given time-point; mean SI 1-20 ϭ mean signal intensity of the first 20 images). Peak height (PH) and time to peak (TTP) of the hyperemic curve were quantified using MATLAB (The Mathworks, Natick, MA, USA).…”

Section: Bold Mrimentioning

confidence: 99%

“…RH has been studied in isolated vessel preparations (10 -12), animal models (13)(14)(15), and clinically (16 -18). Parameters of the RH response have been shown to be reproducible (19,20), provide a simple and inexpensive way to distinguish diseased from healthy individuals (15), and predict disease location (16). Commonly used methods to quantify the RH response include strain-gauge plethysmography and Doppler flowmetry.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Reactive hyperemia and BOLD MRI demonstrate that VEGF inhibition, age, and atherosclerosis adversely affect functional recovery in a murine model of peripheral artery disease

Greve

Williams

Bernstein³

et al. 2008

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To develop magnetic resonace imaging (MRI) methods for functional assessment of arteriogenesis in a murine model of peripheral artery disease to quantify the influences of vascular endothelial growth factor (VEGF), age, and atherosclerosis. Materials and Methods:Reactive hyperemia (RH), which was induced using a device designed for remote and transient occlusion of the aorta and vena cava, was measured by blood-oxygen-level-dependent MRI. Twenty-eight days after femoral artery ligation, peak height (PH) and time to peak (TTP) of the RH response was compared with shamoperated animals in 10-week-old C57Bl6, 9-month-old C57Bl6, and 9-month-old Ldlr Ϫ/Ϫ Apobec Ϫ/Ϫ mice. The contribution of VEGF to functional recovery was assessed in young mice. Angiogenesis was quantified using an anti-PECAM1 radioimmunoassay. Results:In young animals, angiogenesis was maximal 7 days after ligation, whereas functional recovery took 28 days. Inhibition of VEGF eliminated the angiogenesis seen at 7 days and reduced RH (PH, P Ͻ 0.05). At day 28, RH was altered in old (TTP, P Ͻ 0.05) and atherosclerotic (PH, P Ͻ 0.05; TTP, P Ͻ 0.05) animals. RH was different in young, old, and atherosclerotic sham animals. Old and atherosclerotic mice showed reduced angiogenesis. Conclusion:The method presented herein can provide a sensitive assay for the functional assessment of arteriogenesis and highlights the contribution of VEGF, age, and atherosclerosis to this process.

show abstract

Section: Bold Mrimentioning

confidence: 99%

mentioning

confidence: 99%

Reactive hyperemia and BOLD MRI demonstrate that VEGF inhibition, age, and atherosclerosis adversely affect functional recovery in a murine model of peripheral artery disease

Greve

Williams

Bernstein³

et al. 2008

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…For a long time reactive hyperemia has been applied to the diagnosis of peripheral arterial occlusive disease because to study the blood flow only at rest is insufficient. Using a reactive hyperemia test, it is possible not only to differentiate patients with peripheral arterial occlusive disease from normal subjects but also to estimate the severity of the leg ischemia [1][2][3][4][5][6][7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…In this investigation, we applied the PORH test because this method can also be applied to intraoperative measurement. For the PORH test, the following parameters and/or procedures have been used: (1) blood flow by plethysmography [11, (2) pulse reappearance time by plethysmography [31, (3) ankle blood pressure by Doppler ultrasound [4,13,14,16] or plethysmography [2], (4) flow velocity by Doppler ultrasound [5], and (5) blood flow by LDF [8][9][10][11][17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…Changes in ankle pressure were measured plethysmographically or ultrasonographically and it was found that when the severity of the leg ischemia was increased, the decrease in : 61 min. ankle pressure during reactive hyperemia became deeper [2,4,13,14,16]. Ward and Martin [51 studied the flow velocity curve of the Doppler ultrasound method and recommended the half recovery time as a reliable screen for aortoiliac disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Postocclusive reactive hyperemia during vascular reconstruction

Matsubara¹,

Narumi²,

Nagasue³

et al. 1998

Int J Angiol

View full text Add to dashboard Cite

Postocclusive hyperaemic duplex scan: A new method of aortoiliac assessment

Currie

Wilson

Baird

et al. 1995

Journal of British Surgery

View full text Add to dashboard Cite

Aortoiliac duplex scanning, while accurate, is time-consuming and technically demanding. This study aimed to develop a fast, non-invasive screening test for aortoiliac disease. Colour duplex scanning was used to record common femoral Doppler ultrasonographic waveforms following 3 min of arterial occlusion using a thigh cuff in 25 patients with normal aortoiliac segments and 25 patients with significant aortoiliac disease. The latter patients had a prolonged period of postocclusive hyperaemic flow compared with the former. End diastolic velocity, 70 s after cuff release, was a significant discriminant between the two groups (sensitivity of 88 per cent, accuracy of 92 per cent). The postocclusive hyperaemic duplex (PHD) test performed well when used prospectively in a further 50 limbs (sensitivity of 86 per cent, accuracy of 84 per cent). The test was more sensitive than femoral pulse palpation and compared favourably with arteriography. The PHD test provides a simple, noninvasive assessment for aortoiliac disease that can be performed on the initial outpatient clinic visit.

show abstract

Hyperemic Response for Accurate Diagnosis of Arterial Insufficiency

Cited by 11 publications

References 9 publications

Reactive hyperemia and BOLD MRI demonstrate that VEGF inhibition, age, and atherosclerosis adversely affect functional recovery in a murine model of peripheral artery disease

Reactive hyperemia and BOLD MRI demonstrate that VEGF inhibition, age, and atherosclerosis adversely affect functional recovery in a murine model of peripheral artery disease

Postocclusive reactive hyperemia during vascular reconstruction

Postocclusive hyperaemic duplex scan: A new method of aortoiliac assessment

Contact Info

Product

Resources

About