Hyperemesis gravidarum and depression in pregnancy: is there an association?

Hızlı, Deniz; Kamalak, Zeynep; Köşüş, Aydın; Köşüş, Nermin; Akkurt, Gonca

doi:10.3109/0167482x.2012.717129

Cited by 36 publications

(47 citation statements)

References 18 publications

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“…Most of the studies focused on NVP and HG found conflicting results with respect to the development of anxiety and depression disorders [7][8][9]. In addition to these conflicting results, some studies have been criticized for having limitations, including small sample size, lack of control group, lack of objective diagnostic criteria, and inappropriate study design [5,8,10,11]. Hence, the objective of this prospective case-control study was to determine the prevalence and severity of anxiety and depression disorders in patients with NVP using specifically designed and validated tools.…”

Section: Effect Of Nausea and Vomiting On Anxiety And Depression Levementioning

confidence: 99%

Effect of Nausea and Vomiting on Anxiety and Depression Levels in Early Pregnancy

Beyazıt

Şahin

2018

Eurasian J Med

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Objective: Nausea and vomiting of pregnancy (NVP) have been reported to be associated with distinct physiological responses to psychosocial stress. In this study, we aimed to evaluate the impact of nausea and vomiting on anxiety and depression during pregnancy.Materials and Methods: Eighty-three pregnant women with nausea and vomiting and 83 healthy pregnant women were included. All participants completed the demography-and pregnancy-related questionnaire, including Rhodes Index of Nausea and Vomiting, Beck Anxiety Inventory (BAI), and Edinburgh Postnatal Depression Scale (EPDS). Results:The median BAI and EPDS levels were 13 (min-max: 0-43) and 7 (min-max: 0-20) for the study group and 4 (min-max: 0-26) and 4 (min-max: 0-16) for control group, respectively. A univariate analysis revealed a statistically significant increase in terms of BAI levels (p<0.001) between the groups, but no significant difference was observed in terms of EPDS. In a logistic regression analysis, both anxiety (p=0.018) and depression (p=0.022) were found to be affected by NVP. The BAI levels of the NVP group correlated with the severity of NVP. Conclusion:According to the results of the present study, women with severe NVP experienced a higher level of anxiety and depression, which necessitates an extra awareness from healthcare professionals in order to be able to contribute effectively.

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Section: Effect Of Nausea and Vomiting On Anxiety And Depression Levementioning

confidence: 99%

Effect of Nausea and Vomiting on Anxiety and Depression Levels in Early Pregnancy

Beyazıt

Şahin

2018

Eurasian J Med

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“…Other studies have linked HG with an increased risk for depression, anxiety, and mental health difficulties,52,53 and as a result, some advocate psychiatric evaluation 54. One study reported women with HG meet criteria for anxiety and depression in 47% and 48% of cases, respectively 12.…”

Section: Hg and Adverse Maternal Outcomesmentioning

confidence: 99%

Hyperemesis gravidarum: current perspectives

McCarthy¹,

Lutomski²,

Greene³

2014

IJWH

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“…Women demonstrating these symptoms were found to experience difficulty with breast milk production, experience marital difficulties, work and education problems, financial difficulties, as well as poor self-care postpartum [14]. A study using the Beck depression inventory that compared 200 women with hyperemesis with 200 matched controls noted that the depression risk was more than 76-fold in the group with hyperemesis [28]. …”

Section: Maternal Complicationsmentioning

confidence: 99%

Hyperemesis Gravidarum: A Review of Recent Literature

et al. 2017

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Background: In the United States, hyperemesis gravidarum is the most common cause of hospitalization during the first half of pregnancy and is second only to preterm labor for hospitalizations in pregnancy overall. In approximately 0.3-3% of pregnancies, hyperemesis gravidarum is prevalent and this percentage varies on account of different diagnostic criteria and ethnic variation in study populations. Despite extensive research in this field, the mechanism of the disease is largely unknown. Although cases of mortality are rare, hyperemesis gravidarum has been associated with both maternal and fetal morbidity. The current mainstay of treatment relies heavily on supportive measures until improvement of symptoms as part of the natural course of hyperemesis gravidarum, which occurs with progression of gestational age. However, studies have reported that severe, refractory disease manifestations have led to serious adverse outcomes and to termination of pregnancies. Summary: Despite extensive research in the field, the pathogenesis of hyperemesis gravidarum remains unknown. Recent literature points to a genetic predisposition in addition to previously studied factors such as infectious, psychiatric, and hormonal contributions. Maternal morbidity is common and includes psychological effects, financial burden, clinical complications from nutritional deficiencies, gastrointestinal trauma, and in rare cases, neurological damage. The effect of hyperemesis gravidarum on neonatal health is still debated in literature with conflicting results regarding outcomes of birth weight and prematurity. Available therapy options remain largely unchanged in the past several decades and focus on parenteral antiemetic medications, electrolyte repletion, and nutritional support. Most studies of therapeutic options do not consist of randomized control studies and cross-study analysis is difficult due to considerable variation of diagnostic criteria. Key Messages: Hyperemesis gravidarum carries a significant burden on maternal health and US health care. Most published research on pathogenesis is observational and suggests multifactorial associations with hyperemesis gravidarum. Precise, strictly defined criteria for clinical diagnosis are likely to benefit meta-analyses of further research studies regarding pathogenesis as well as therapeutic options.

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Hyperemesis gravidarum and depression in pregnancy: is there an association?

Abstract: Depression risk is increased in patients with HG, therefore not only medical therapy of HG, but also psychiatric evaluation should be considered for these patients.

Cited by 36 publications

References 18 publications

Effect of Nausea and Vomiting on Anxiety and Depression Levels in Early Pregnancy

Effect of Nausea and Vomiting on Anxiety and Depression Levels in Early Pregnancy

Hyperemesis gravidarum: current perspectives

Hyperemesis Gravidarum: A Review of Recent Literature

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