Hyperelastic Nanocellulose-Reinforced Hydrogel of High Water Content for Ophthalmic Applications

Tummala, Gopi Krishna; Joffre, Thomas; Lopes, Viviana R.; Liszka, Aneta; Buznyk, Oleksiy; Ferraz, Natalia; Persson, Cecilia; Griffith, May; Mihranyan, Albert

doi:10.1021/acsbiomaterials.6b00484

Cited by 68 publications

(54 citation statements)

References 30 publications

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“…37 The material also showed cytocompatibility with human corneal epithelial cells and was suturable on a porcine cornea. 38 The unique properties of PVA and nanocellulose combined, make the hydrogel a good contender for contact lens and other ocular applications.…”

Section: Introductionmentioning

confidence: 99%

Strain-induced stiffening of nanocellulose-reinforced poly(vinyl alcohol) hydrogels mimicking collagenous soft tissues

et al. 2017

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Soft tissues possess remarkable mechanical strength for their high water content, which is hard to mimic in synthetic materials. Here, we demonstrate how strain-induced stiffening in hydrogels plays a major role in mimicking the mechanical properties of collagenous soft tissues. In particular, nanocellulose reinforced polyvinyl alcohol (PVA) hydrogels of exceptionally high water content (90-93 wt%) are shown to exhibit collagen-like mechanical behavior typical for soft tissues. High water content and co-existence of both soft and rigid domains in the gel network are the main factors responsible for strain-induced stiffening. This observed effect due to the alignment of rigid components of the hydrogel is simulated through modeling and visualized through strain-induced birefringence experiments. Design parameters such as nanocellulose aspect ratio and solvent composition are also shown to be important to control the mechanical properties. In addition, owing to their transparency (90-95% at 550 nm) and hyperelastic properties (250-350% strain), the described hydrogels are promising materials for biomedical applications, especially in ophthalmology.

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Section: Introductionmentioning

confidence: 99%

Strain-induced stiffening of nanocellulose-reinforced poly(vinyl alcohol) hydrogels mimicking collagenous soft tissues

et al. 2017

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“…Hydrogels with high water content have wide applications in biomaterials, biomedical, and agriculture fields, such as drug delivery and release, ophthalmic lens, bone repair, seed germination, and seedling growth, benefiting from their excellently biocompatible, environmentally friendly, and rapidly stimuli‐responsive features. In recent years, several novel hydrogels with high water content have been developed, and some are with very high water content, for example, polyethylene glycol‐containing hydrogels (97.5–99.4 wt%), noncovalent interactions and Diels–Alder chemical bonds dually cross‐linked hydrogels (98 wt%), graphene oxide/hemoglobin composite hydrogels (98.5 wt%), star‐block quaternized poly(2‐(dimethylamino)ethyl methacrylate)‐poly(di(ethylene glycol)methyl ether methacrylate) copolymer hydrogels (98.9–99.2 wt%), cucurbit[8]uril complexed supramolecular hydrogels (99.5–99.7 wt%), cellular‐structured nanofibrous hydrogels (99.8 wt%) .…”

Section: Methodsmentioning

confidence: 99%

Tough, Stimuli‐Responsive, and Biocompatible Hydrogels with Very High Water Content

Liu

Lü

Peng

et al. 2018

Macromol. Rapid Commun.

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Some marine creatures like jellyfish have gel‐like bodies consisting mostly of water (above 95 wt%). Yet, their gel‐like bodies still show quite good mechanical properties and can respond to external stimuli. Artificial hydrogels with very high water content are generally extremely weak, and hence their practical applications are strongly limited. Inspired by jellyfish, tough and biocompatible poly(vinyl alcohol)/sodium polyacrylate (PVA/PAANa) hydrogels with very high equilibrium water content (98.23–99.58 wt%) are developed. The equilibrium swollen PVA/PAANa hydrogels show good mechanical properties, with elastic modulus, tensile strength, and elongation up to 0.046 MPa, 0.14 MPa, and 206%, respectively, very close to those of jellyfish mesoglea. Moreover, the PVA/PAANa hydrogels can respond to external multi‐stimuli distinctly, such as metal cations, pH, and salts. Very impressively, the PVA/PAANa hydrogel can easily distinguish tap water from deionized water, and its detection limit of metal cations can be as low as 10−4 mol L−1. Cell cytotoxicity tests and in vivo biocompatibility tests prove that the PVA/PAANa hydrogels have excellent biocompatibility. The tough, stimuli‐responsive, and biocompatible hydrogels with very high water content may find a variety of practical applications in load‐bearing biomaterials, detection, sensors, and agricultural fields.

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“…Poly(vinyl alcohol) (PVA)–cellulose composite are becoming the preferred choice as biodegradable plastics, absorbents, and scaffolds for tissue engineering . Although both PVA and cellulose differ in their origin and properties, both are biodegradable and biocompatible.…”

Section: Introductionmentioning

confidence: 99%

“…Tummala et al . prepared hyperelastic contact lenses using PVA–cellulose nanocrystal hydrogels . Anisotropic bacterial cellulose–PVA nanocomposite is prepared for biomedical applications .…”

Section: Introductionmentioning

confidence: 99%

Rapid synthesis of high strength cellulose–poly(vinyl alcohol) (PVA) biocompatible composite films via microwave crosslinking

Sonker

Rathore

Teotia

et al. 2018

J of Applied Polymer Sci

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The present study describes microwave (MW)-assisted rapid synthesis of biocompatible poly(vinyl alcohol) (PVA) composite films that demonstrate synergy between reinforcement and crosslinking. Bacterial cellulose (5% w/w) nanowhiskers (reinforcement) and tartaric acid 35% (w/w) (crosslinker) are incorporated in PVA to prepare crosslinked cellulose-PVA composite films. The properties of thus prepared crosslinked cellulose-PVA composite films are compared with samples crosslinked with conventional hot air oven heating (CH). Crosslinking by both of the methods reduces water absorption of PVA by around an order of magnitude and improves its thermal stability. An increase in strength from 42 (PVA) to 172 MPa and 159 MPa for MW and CH crosslinked samples, respectively is also observed. Although composites prepared using MW and CH show similar properties, MW takes only 14 min compared to 2 h in case of CH. Notably, the prepared composites demonstrate hemocompatibility and cytocompatibility, and may also be explored for biomedical applications.

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Hyperelastic Nanocellulose-Reinforced Hydrogel of High Water Content for Ophthalmic Applications

Cited by 68 publications

References 30 publications

Strain-induced stiffening of nanocellulose-reinforced poly(vinyl alcohol) hydrogels mimicking collagenous soft tissues

Strain-induced stiffening of nanocellulose-reinforced poly(vinyl alcohol) hydrogels mimicking collagenous soft tissues

Tough, Stimuli‐Responsive, and Biocompatible Hydrogels with Very High Water Content

Rapid synthesis of high strength cellulose–poly(vinyl alcohol) (PVA) biocompatible composite films via microwave crosslinking

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