Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients

Rahman, Annas; Ruge, Max; Hlepas, Alex; Nair, Gatha; Gomez, Joanne Michelle D.; Lavallaz, J Du Fay De; Fugar, Setri; Jahan, Nusrat; Volgman, Annabelle Santos; Williams, Kim A.; Rao, Anupama; Marinescu, Karolina; Suboc, Tisha

doi:10.1016/j.ahjo.2022.100134

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…We also performed the sensitivity analysis including two studies assessing the impact of hyperdynamic LV systolic function in general critically ill patients and patients [ 9 ] with coronavirus disease 2019 [ 30 ]. In this sensitivity analysis, the adjusted OR was used in four studies [ 7 , 9 , 19 , 30 ] and the unadjusted OR was used in the rest of two studies [ 20 , 21 ]. We found a pooled OR of short-term mortality associated with hyperdynamic LV systolic function of 1.76 (95%CI 1.30, 2.37); I 2 = 57.3%; P < 0.039, Additional file 2 : Fig.…”

Section: Resultsmentioning

confidence: 99%

“…First, it describes the prevalence of hyperdynamic LV systolic function in the context of sepsis and its association with short-term mortality. In cohorts of critically ill patients [ 9 ] and in hospitalized coronavirus disease 2019 patients [ 30 ], hyperdynamic LV systolic function defined by LVEF > 70% was associated with significantly higher short-term mortality. This significant association between hyperdynamic LV systolic function and mortality, regardless of whether an underlying condition is sepsis or not, may suggest that hyperdynamic LV systolic function is a pathogenic condition requiring clinical attention.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis

Sato,

Sanfilippo,

Hasegawa

et al. 2024

Ann. Intensive Care

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Purpose The prevalence of hyperdynamic left ventricular (LV) systolic function in septic patients and its impact on mortality remain controversial. In this systematic review and meta-analysis, we investigated the prevalence and association of hyperdynamic LV systolic function with mortality in patients with sepsis. Methods We searched MEDLINE, Cochrane Central Register of Controlled Trials, and Embase. Primary outcomes were the prevalence of hyperdynamic LV systolic function in adult septic patients and the associated short-term mortality as compared to normal LV systolic function. Hyperdynamic LV systolic function was defined using LV ejection fraction (LVEF) of 70% as cutoff. Secondary outcomes were heart rate, LV end-diastolic diameter (LVEDD), and E/e’ ratio. Results Four studies were included, and the pooled prevalence of hyperdynamic LV systolic function was 18.2% ([95% confidence interval (CI) 12.5, 25.8]; I2 = 7.0%, P < 0.0001). Hyperdynamic LV systolic function was associated with higher mortality: odds ratio of 2.37 [95%CI 1.47, 3.80]; I2 = 79%, P < 0.01. No difference was found in E/e’ (P = 0.43) between normal and hyperdynamic LV systolic function, while higher values of heart rate (mean difference: 6.14 beats/min [95%CI 3.59, 8.69]; I2 = 51%, P < 0.0001) and LVEDD (mean difference: − 0.21 cm [95%CI − 0.33, − 0.09]; I2 = 73%, P < 0.001) were detected in patients with hyperdynamic LV systolic function. Conclusion The prevalence of hyperdynamic LV systolic function is not negligible in septic patients. Such a finding is associated with significantly higher short-term mortality as compared to normal LV systolic function.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis

Sato,

Sanfilippo,

Hasegawa

et al. 2024

Ann. Intensive Care

View full text Add to dashboard Cite

show abstract

“…Reduced peripheral vascular tone and excessive of catecholamine in sepsis patients lead to a hyperdynamic state of the heart [57]. Studies have shown that a prolonged cardiac hyperdynamic state can lead to septic cardiomyopathy, leading to a poor overall prognosis for patients [58][59][60]. Critical care ultrasound can rapidly assess the systolic function of the heart by eyeballing, which has a high correlation with indicators of left ventricular systolic function such as LVEF and MAPSE [61].…”

Section: Sepsismentioning

confidence: 99%

Assessment of Pulmonary Circulation of Critically Ill Patients Based on Critical Care Ultrasound

Gong,

Ding,

Wang

2024

JCM

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Pulmonary circulation is crucial in the human circulatory system, facilitating the oxygenation of blood as it moves from the right heart to the lungs and then to the left heart. However, during critical illness, pulmonary microcirculation can be vulnerable to both intrapulmonary and extrapulmonary injuries. To assess these potential injuries in critically ill patients, critical point-of-care ultrasound can be used to quantitatively and qualitatively evaluate the right atrium, right ventricle, pulmonary artery, lung, pulmonary vein, and left atrium along the direction of blood flow. This assessment is particularly valuable for common ICU diseases such as acute respiratory distress syndrome (ARDS), sepsis, pulmonary hypertension, and cardiogenic pulmonary edema. It has significant potential for diagnosing and treating these conditions in critical care medicine.

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Ultrasound-Guided Goal-Directed Therapy in the Critically Ill Patient

Deschamps,

Zeleznak,

Sarebanha

et al. 2024

Curr Anesthesiol Rep

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Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients

Cited by 4 publications

References 20 publications

Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis

Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis

Assessment of Pulmonary Circulation of Critically Ill Patients Based on Critical Care Ultrasound

Ultrasound-Guided Goal-Directed Therapy in the Critically Ill Patient

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