Hypercoagulability in Rheumatoid Arthritis: A Bibliometric Analysis and Retrospective Data Mining Study

Abstract

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation, leading to joint deformities and functional loss. RA progression is accompanied by abnormalities in the coagulation–fibrinolysis system, clinically manifested as a hypercoagulable state. However, there are currently no bibliometrics or visualization analysis in this field. Objective: The present study aims to reveal the knowledge structure, research status, and research trends related to hypercoagulability in RA through bibliometric analysis and to evaluate the utility of inflammatory and coagulation markers in RA disease activity through retrospective data mining. Methods: English articles and reviews on RA hypercoagulability published from 2010 to 2023 were extracted from the Web of Science Core Collection (WoSCC) database on March 1, 2023. VOSviewer and CiteSpace software were used for knowledge mapping analysis of the included papers in terms of countries/regions, institutions, journals, authors, keywords, research hotspots, and frontiers. A retrospective analysis was conducted on the general information on RA patients. The demographic and clinical indicators of all participants were collected to determine the correlation of inflammatory and coagulation markers with the Chinese patient-reported activity index for rheumatoid arthritis (CPRI-RA). Results: A total of 957 papers were retrieved. The United States was the most productive country in this field and had the highest h-index, and the most prolific institution was the Karolinska Institute. The Annals of the Rheumatic Diseases was the journal with the most publications, and KLARESKOG L. was the most productive author. From keyword analysis, it could be seen that “inflammation”, “activation”, “disease-activity”, and “risk” had long been the focuses of RA hypercoagulability research. “Criteria”, “validation”, “coagulation”, “target”, and “anemia” were the latest popular keywords in the past 5 years. Retrospective data mining revealed that the levels of inflammation (RF, ESR, and CRP) and coagulation (PLT and DD) were significantly increased in RA patients. FBG, CRP, and ESR were significantly correlated with CPRI-RA. Additionally, ESR, CRP, and FBG were identified as independent risk factors for CPRI-RA. Conclusion: The mechanism and application of hypercoagulability in RA have been research hotspots in recent years. Inflammation and coagulation markers are independent risk factors for CPRI-RA.

Under the dual effect of inflammation and pulmonary fibrosis, CTD-ILD patients possess a greater susceptibility to VTE

“…Inflammatory activity triggers the formation of a hypercoagulable state with concomitant changes in D-dimer [ 25 ]. Several investigators have confirmed the correlation between D-dimer levels and rheumatoid arthritis activity indices through retrospective data mining [ 26 ]. In addition to its predictive value for the diagnosis of VTE in CTD patients [ 27 ], it has been shown that D-dimer level is also a valid serologic index for assessing disease activity in some CTD patients [ 28 , 29 ].…”

Insights into Ionic Liquids for Oil Desulfurization: A Study Based on Bibliometric Mapping

“…Bibliometrics is an emerging overview analysis, which can systematically analyze topics regarding research trends, status, and hotspots . More importantly, bibliometrics can handle a large amount of literature data . With the help of literature visualization tools, existing research gaps can be identified, and emerging research ideas can be revealed more rigorously .…”

A systematic review and meta‐analysis of the association between the D‐dimer and rheumatic diseases

“…[4][5][6][7][8][9][10][11][12][13][14][15][16] One important factor contributing to the health burden of RDs on patients and healthcare systems is represented by a state of hypercoagulability with a predisposition to venous thromboembolism (VTE). 17,18 This issue has been well studied in specific RDs, for example, RA (increased risk of VTE by a factor of 2−2.5 vs. general population), [19][20][21] systemic lupus erythematosus (SLE, increased risk of VTE by a factor of 4.38 vs. general population), 22,23 systemic sclerosis (SSc) (increased risk of VTE by a factor of 2.5 vs. general population), 24 ANCA-associated vasculitis (AAV) (increased risk of VTE by a factor of 3.26 vs. general population), [25][26][27][28][29][30][31] CA and gout (increased risk of VTE by a factor of 1.33 vs. general population), 32 osteoarthritis (OA) (increased risk of VTE by a factor of 1.38 vs. general population), 33 and Behcet disease (BD) (increased risk of VTE by a factor of 2.80 vs. general population). [34][35][36][37] It is commonly accepted that the proinflammatory and pro-oxidant state in patients with RA and SLE favors the upregulation of procoagulant pathways and the downregulation of anticoagulant and fibrinolytic pathways.…”