Hypercoagulability in celiac disease — An update

Risk of venous thromboembolism in patients with celiac disease: A systematic review and meta‐analysis

“…Other possible explanations include genetic predisposition methylenetetrahydrofolate reductase (MTHFR mutations), platelet abnormality, and autoimmune homology between tissue transgluminase and factor XIII …”

“…Other possible explanations include genetic predisposition methylenetetrahydrofolate reductase (MTHFR mutations), platelet abnormality, and autoimmune homology between tissue transgluminase and factor XIII. 30 Even though the primary studies included in this meta-analysis were of high quality as reflected by the high-quality assessment scores, we acknowledged that there were some limitations. Thus, the results of our study should be interpreted with caution.…”

Stroke revealing celiac disease associated with multiple arterial thrombotic locations

“…To our knowledge, this is the first report of a multiple arterial thrombotic case associated with a CD. The cause of the vascular disorders seen in patients with CD remains controversial [9]. The presence of thrombophilic risk factors for thrombosis, such as protein S deficiency, hyperhomocysteinemia, or antiphospholipid antibodies, was reported depending on the case, although, our patient had none of these thrombophilic factors.…”

‘Autoimmunity cutting edge at the 21st century. Representation of the 9th International Congress of Autoimmunity, Nice, France 2014’

“…A wind of change that is blowing in the management of celiac disease. Lerner and Blank [23] remarkably displayed the concomitant association between hypercoagulable autoimmune diseases and celiac. The presence of SLE and/or antiphospholipid antibodies and of other prothrombotic states such as nutritional deficiencies of B12 and folate, protein C and S deficiencies due to vitamin K deficiency, genetic thrombophilia, accelerated atherosclerosis with endothelial dysfunction and finally, platelet abnormalities may combine to bring about a condition of hypercoagulability.…”