Hypercitricemia in Human Cancer. Factors concerned in Pathogenesis and Treatment

Abstract

PATIENTS with leukemia, metastatic carcinoma and sarcoma possess altered carbohydrate metabolism as shown by reduced glucose tolerance (Marks and Bishop, 1957), and elevated resting venous lactic acid (Cori and Cori, 1925). Enzymes concerned in tissue glycolysis are often increased in activity in serum during neoplastic disease progression, including phosphohexose isomerase (Bodansky, 1954b), aldolase (Sibley Fleischer and Higgins, 1955), and lactic dehydrogenase (Hill and Levi, 1954). Acid phosphomonoesterases hydrolyzing three-carbon substrates produced during glycolysis are also increased in activity in venous blood from patients with breast and prostate cancer (Reynolds, Lemon and Byrnes, 1956