Hyperchromatic-crowded groups (HCG) in pap smears

Abada, Evi; George, Kathleen M.; Shidham, Vinod B.

doi:10.25259/cytojournal_76_2019

Cited by 2 publications

(1 citation statement)

References 16 publications

(34 reference statements)

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“…On a low-power screening, multiple three-dimensional HCGs or two-dimensional sheets or strips of hyperchromatic cells can be identified with variable degree of overlapping. [ 16 , 17 ]…”

Section: Glandular Cell Abnormalitiesmentioning

confidence: 99%

Atypical glandular cells (AGC): Cytology of glandular lesions of the uterine cervix

Khan¹,

Bandyopadhyay²,

Alrajjal³

et al. 2022

Cytojournal

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The Pap smear is a well-known screening tool for squamous lesions of the uterine cervix. However, its screening role in glandular lesions is less effective. The incidence of squamous cell carcinoma of the cervix has dramatically decreased with the advent of Pap smear and recent understanding related to HPV carcinogenesis of cervical cancers including the advent of HPV vaccines. However, in recent years, the incidence of glandular abnormalities, diagnosed on Pap smears, has increased with greater sensitivity and precision. The incidence of atypical glandular cells (AGC) is approximately 0.18–0.74% of all cervical smears with a reported prevalence of 2.5% among all Pap smears. A high degree of suspicion, good clinical history, and the presence of diagnostic cytomorphological findings are essential for the proper interpretation of glandular cell abnormalities. A methodical approach to evaluate Pap smear greatly helps interpretation and avoids the diagnostic pitfalls. The Bethesda System for reporting cervical cytology has categorized glandular cell abnormalities into various categories as follows: Endocervical adenocarcinoma in situ (AIS) Atypical glandular cells (AGCs) Endocervical cells: a1 NOS or specify in comments; a2 Favor neoplastic Endometrial cells: NOS or specify in comments Adenocarcinoma (AdCa) Endocervical Endometrial Extrauterine NOS Subtle differences in quantitative and qualitative cytologic features are essential for distinguishing one category from another. In this chapter, we highlight an organized approach for the interpretation of glandular abnormalities in Pap smear for our readers. This is an overview of the Bethesda categories, the reason for classification, and differential diagnosis with key characteristic features. An approach to the methodical evaluation of hyperchromatic crowded groups is discussed with key cytomorphologic differences. An algorithmic approach is suggested to facilitate the interpretation of various AGC categories.

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“…On a low-power screening, multiple three-dimensional HCGs or two-dimensional sheets or strips of hyperchromatic cells can be identified with variable degree of overlapping. [ 16 , 17 ]…”

Section: Glandular Cell Abnormalitiesmentioning

confidence: 99%

Atypical glandular cells (AGC): Cytology of glandular lesions of the uterine cervix

Khan¹,

Bandyopadhyay²,

Alrajjal³

et al. 2022

Cytojournal

View full text Add to dashboard Cite

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Architectural aspects of cell-blocks as small biopsies

Satturwar

Pantanowitz

2021

Cytojournal

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Cell-block preparations have become an essential part of integrated cytology diagnosis. They are essentially microbiopsies that are formalin fixed and embedded in paraffin. This has become more prevalent with greater sample procurement due to the advent of newer biopsy techniques and needles. Cell-blocks allow retrieval of small tissue fragments from cytology specimens that sometimes cannot be processed by alternate cytologic techniques. They represent concentrated, cell-enriched preparations that provide cytologists with the opportunity to evaluate cellular architecture, as well as to perform ancillary testing. A cell-block compatible sample may thus obviate the need for a more invasive procedure such as a tissue biopsy. Microscopic examination of cell-blocks is quick, avoids obscuring material, permits cells to be evaluated in one focal plane, and allows the histologic architecture such as glandular differentiation, papillary formations, and sometimes invasion to be easily identified. This new era of “cytohistology” accordingly requires practicing cytologists to become more familiar with histopathology. This review article discusses the benefit of various architectural patterns identifiable in cell-blocks employed as an adjunct to Pap tests, exfoliative fluid specimens, and fine-needle aspirations.

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Hyperchromatic-crowded groups (HCG) in pap smears

Cited by 2 publications

References 16 publications

Atypical glandular cells (AGC): Cytology of glandular lesions of the uterine cervix

Atypical glandular cells (AGC): Cytology of glandular lesions of the uterine cervix

Architectural aspects of cell-blocks as small biopsies

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