Abstract:Pulmonary surfactant is a lipoprotein complex necessary for lung function. The importance of surfactant is evident in Acute lung injury (ALI) in which the dysfunction of surfactant is thought to contribute to the hypoxemia characterizing the disease. Recent studies have specifically implicated elevated levels of cholesterol within surfactant as a mechanism for its dysfunction. It is not known if this effect is dependent on serum cholesterol. It was hypothesized that diet‐induced serum hypercholesterolemia affe… Show more
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