Hypercholesterolaemia screening in type 1 diabetes - a difference of opinion

Candler, Toby; Mahmoud, Osama; Edge, Julie; Hamilton-Shield, Julian

doi:10.1530/endoabs.45.oc7.1

Cited by 2 publications

(3 citation statements)

References 1 publication

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“…Some diabetes clinics did not update their policy (yet) in response to the most recent ISPAD guidelines and most of them do not personalize the screening. This variance in practice and adherence to guidelines in pediatric diabetes care was also described by several other authors 8‐12 …”

Section: Discussionsupporting

confidence: 62%

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Screening for complications and associated conditions in children, adolescents and young adults with Type 1 diabetes mellitus in the Netherlands: Big differences in a small country

2021

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Introduction: Children, adolescents and young adults with Type 1 diabetes mellitus need to be screened for chronic complications and associated (autoimmune) diseases.There are no Dutch national guidelines for screening available but the International Society for Pediatric and Adolescent Diabetes (ISPAD) gives recommendations in its guidelines. The ISPAD guidelines from 2014 were updated in 2018.Objectives: The adherence of the Dutch pediatric diabetes clinics to the international guidelines as stated by the ISPAD.Methods: A questionnaire about screening method and frequency was send to all members of the Dutch national committee for pediatric diabetes. The screening policies of the pediatric diabetes clinics were compared to the ISPAD guidelines of 2014 and 2018.Results: Sixty-two percent of all diabetes clinics filled out the questionnaire. None of the diabetes clinics followed all recommendations of the ISPAD. The majority of the clinics had a higher frequency of screening, performed extra blood tests and did not personalize their policy to the individual patient. Approximately one third of the diabetes clinics still commenced screening for chronic complications at the age of 10 years, as recommended in the previous version of the ISPAD guideline.Conclusions: Dutch pediatric diabetes clinics screen their patients on chronic complications and associated conditions very differently and not according to the international (and most recent) guidelines. A more individualized approach with respect to the newest ISPAD guidelines will diminish the burden for the patient and medical costs as well.

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Section: Discussionsupporting

confidence: 62%

“…This variance in practice and adherence to guidelines in pediatric diabetes care was also described by several other authors. [8][9][10][11][12] There are several possible reasons for the variances we found.…”

Section: Discussionmentioning

confidence: 94%

Screening for complications and associated conditions in children, adolescents and young adults with Type 1 diabetes mellitus in the Netherlands: Big differences in a small country

2021

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“…Good glycemic control helps to delay or prevent complications (16). T1DM patients are often accompanied by dyslipidemia, and dyslipidemia is an important risk factor for cardiovascular disease (17). Therefore, evaluating the risk factors that affect glucose and lipid metabolism disorders in TIDM patients is especially important.…”

Section: Discussionmentioning

confidence: 99%

The thyroid hormone levels and glucose and lipid metabolism in children with type 1 diabetes: a correlation analysis

Yuan¹,

Sun²,

Liu³

et al. 2021

Transl Pediatr

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Background: Type 1 diabetes mellitus (T1DM) is common in clinical setting, the relationship between thyroid hormone levels and glucose and lipid metabolism in patients with T1DM remains unclear. We attempted to analyze the correlation of thyroid hormone levels and blood glucose and lipid metabolism in children with normal thyroid function.Methods: Children with T1DM were selected, and 85 healthy children who underwent physical examinations in our hospital as control group. The characteristics and laboratory testing results were compared, the correlation of thyroid hormone levels with blood glucose and blood lipids was analyzed by Pearson correlation analysis. Results: A total of 167 participants were included. the low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), fasting blood glucose (FBG), and glycated hemoglobin (HbAlc) in T1DM patients were higher than those in healthy controls, while the high-density lipoprotein-cholesterol (HDL-C), thyroid stimulating hormone (TSH) and free triiodothyronine (FT3) in T1DM patients were lower than that of healthy children (all P<0.05). TSH was positively correlated with LDL-C (r=0.169, P=0.032), TC (r=0.182, P=0.017) and TG (r=0.197, P=0.008), negatively correlated with FBG (r=−0.196, P=0.023) and HbAlc (r=−0.328, P=0.002). FT3 was negatively correlated with TG (r=−0.182, P=0.011), FBG (r=−0.184, P=0.009)and HbAlc (r=−0.223, P=0.005). TG in the high TSH group and the middle TSH group is higher than that of low TSH group. However, FBG and HbAlc were lower than those in the low TSH group (all P<0.05).Compared with the low FT3 group, the TG, FBG and HbAlc decreased in the high and middle FT3 group (all P<0.05). Conclusions:The serum TSH are closely associated with FT3 and glycolipid metabolism in children with T1DM, which may be the useful indicators to assess the severity of T1DM in clinical settings to provide insights into the management of T1DM.

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Hypercholesterolaemia screening in type 1 diabetes - a difference of opinion

Cited by 2 publications

References 1 publication

Screening for complications and associated conditions in children, adolescents and young adults with Type 1 diabetes mellitus in the Netherlands: Big differences in a small country

Screening for complications and associated conditions in children, adolescents and young adults with Type 1 diabetes mellitus in the Netherlands: Big differences in a small country

The thyroid hormone levels and glucose and lipid metabolism in children with type 1 diabetes: a correlation analysis

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