Hypercholesteremia and nicotinic acid

Effects of acipimox on haemorheology and plasma lipoproteins in patients with mixed hyperlipoproteinaemia

“…Although generally well tolerated, acipimox therapy induced a slight but significant increase in uric acid concentration (10.3±2.7%). Similar changes have been observed with nicotinic acid [ 21]. Since the risk of gout depends on the absolute concentration [ 22] this increase is clinically irrelevant in patients with normal baseline uric acid concentration.…”

Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.

“…We now report that pyrazinoate and nicotinate, another substance that causes urate retention (10), are substrates for the dog renal microvillus membrane anion exchange pathway shared by urate. Moreover, pyrazinoate and nicotinate are also substrates for an organic anion-Na+ cotransport pathway not shared by urate.…”

Treatment of Hypercholesterolemia: Comparison of Younger versus Older Patients Using Wax‐Matrix Sustained‐Release Niacin

“…Impaired glucose tolerance and the potential adverse effects of the resultant hyperinsulinemia have been described in subjects treated with nicotinic acid 21 , 22 . This appears to be particularly a concern in the case of non‐insulin dependent diabetics when treated with nicotinic acid 21 .…”