Hyperchloremia – Why and how

Nagami, Glenn T.

doi:10.1016/j.nefro.2016.04.001

Cited by 37 publications

(26 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This discrepancy might be explained by the fact that ~50% of the participants in the present study had been taking a calcium-containing phosphate binder, which has been reported to be positively associated with HCO 3 concentration [16]. HCO 3 concentration is known to decrease as chloride concentration increases because of the equilibrium between HCl and NaHCO 3 : H + + Cl -+ Na + + HCO 3 -= Na + + Cl -+ H 2 CO 3 [17]. In the present study, chloride concentration was negatively correlated with HCO 3 concentration, which is compatible with the findings of a previous study [10].…”

Section: Discussionmentioning

confidence: 62%

Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Hirai

Ookawara

Morino

et al. 2020

Kidney Res Clin Pract

View full text Add to dashboard Cite

Background: Few studies have investigated the relationship between serum total carbon dioxide (CO 2) concentration and bicarbonate ion (HCO 3-) concentration in patients undergoing hemodialysis. We determined the agreement and discrepancy between serum total CO 2 and HCO 3 concentrations and the diagnostic accuracy of serum total CO 2 for the prediction of low (HCO 3-< 24 mEq/L) and high (HCO 3-≥ 24 mEq/L) bicarbonate concentrations in hemodialysis patients. Methods: One hundred forty-nine arteriovenous blood samples from 84 hemodialysis patients were studied. Multiple linear regression analysis was used to determine factors correlated with HCO 3 concentration. Diagnostic accuracy of serum total CO 2 was evaluated using receiver operating characteristic curve analysis and a 2 × 2 table. Agreement between serum total CO 2 and HCO 3 concentrations was assessed using Bland-Altman analysis. Results: Serum total CO 2 concentration was closely correlated with HCO 3 concentration (β = 0.858, P < 0.001). Area under the curve of serum total CO 2 for the identification of low and high bicarbonate concentrations was 0.989. Use of serum total CO 2 to predict low and high bicarbonate concentrations had a sensitivity of 100%, specificity of 50.0%, positive predictive value of 96.5%, negative predictive value of 100%, and accuracy of 96.6%. Bland-Altman analysis showed moderate agreement between serum total CO 2 and HCO 3 concentrations. Discrepancies between HCO 3 and serum total CO 2 concentrations (serum total CO 2-HCO 3-≤-1) were observed in 89 samples. Conclusion: Serum total CO 2 concentration is closely correlated with HCO 3 concentration in hemodialysis patients. However, there is a non-negligible discrepancy between serum total CO 2 and HCO 3 concentrations.

show abstract

Section: Discussionmentioning

confidence: 62%

Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Hirai

Ookawara

Morino

et al. 2020

Kidney Res Clin Pract

View full text Add to dashboard Cite

show abstract

“…We identified two previously unappreciated findings related to hyperchloremia and hypocalcemia one day following EHS injury. Elevated chloride values are likely benign, and a direct result of extensive intravenous normal saline use during the course of immediate EHS treatment [34]. It is unclear from this study if hyperchloremia findings are clinically actionable.…”

Section: Interpreting Clinical Laboratory Values and Implications Fomentioning

confidence: 82%

Biochemical recovery from exertional heat stroke follows a 16-day time course

et al. 2020

View full text Add to dashboard Cite

BackgroundThe aim of this study was to characterize the time-resolved progression of clinical laboratory disturbances days-following an exertional heat stroke (EHS). Currently, normalization of organ injury clinical biomarker values is the primary indicator of EHS recovery. However, an archetypical biochemical recovery profile following EHS has not been established. MethodsWe performed a retrospective analysis of EHS patient records in US military personnel from 2008-2014 using the Military Health System Data Repository (MDR). We focused on commonly reported clinical laboratory analytes measured on the day of injury and all proceeding follow-up visits. ResultsOver the prescribed period, there were 2,529 EHS episodes treated at 250 unique treatment locations. Laboratory results, including a standardized set of blood, serum and urine assays, were analyzed from 0-340 days following the initial injury. Indicators of acute kidney injury, including serum electrolyte disturbances and abnormal urinalysis findings, were most prevalent on the day of the injury but normalized within 24-48hours (creatinine, blood urea nitrogen, and blood and protein in urine). Muscle damage and liver function-associated markers peaked 0-4 days after injury and persisted outside their respective reference ranges for 2-16 days (alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, myoglobin, prothrombin time). ConclusionBiochemical recovery from EHS spans a 16-day time course, and markers of end-organ damage exhibit distinct patterns over this period. This analysis underscores the prognostic value of each clinical laboratory analyte and will assist in evaluating EHS patient presentation, injury severity and physiological recovery.

show abstract

“…While potassium levels in the blood increase due to Potassium accumulates in the blood due to the main decrease in kidney function, in the event of kidney failure kidneys could not get rid of the amount of potassium overload the body's need, so there is an excess of potassium levels [30]. Also increase chloride levels in pre dialysis due to the body's loss of large quantities of fluids, which are free of chloride, leading to high concentration of ions in the body as in drought, thus reducing the flow of renal blood, and due also to increased metabolic acid in the blood as a result of the inability of the kidneys to get rid of excess acidity and therefore occur hyperchloremia [31]. (P ≤ 0.05) significant(S), (P ≥ 0.05) non-significant (N.S), (P ≤ 0.01) highly significant (H.S).…”

Section: Resultsmentioning

confidence: 99%

Study of the Anti-Diuretic Hormone (ADH) on End Stage Renal Failure Disease (ESRD) Pre-Hemodialysis in Iraqi Patients

Al-Taiee¹,

Al-Shammaa²,

Aljber³

2019

IHJPAS

View full text Add to dashboard Cite

Chronic renal disease (CRD) is a pathophysiologic process with multiple etiologies, resulting in the inexorable attrition of Nephron number and function and frequently leading to end-stage renal disease (ESRD). In turn, ESRD represents a clinical state or condition in which there has been an irreversible loss of endogenous renal function, of a degree sufficient to render the patient permanently dependent upon renal replacement therapy (dialysis of transplantation) in order to avoid life threatening uremia, reflecting a dysfunction of all organ systems as a result of untreated or under treated acute or chronic renal failure. The current study was involved 80 patients, the age range within 25-70 years, selected sample of patients who attend Iraqi center of kidney dialysis, Baghdad Teaching Hospital and Al-Yarmok Teaching Hospital. All the patient's body mass index [BMI] were measured serum anti diuretic hormone ADH was assessed using enzyme linked immunosorbent kit [Elisa] while urea, creatinine, albumin, hemoglobin were determined by spectrophotometer (PD-303), and sodium, potassium, chloride were determined by Electrolyte analyzer 9180.These patients were divided in two group B (40 patients) as pre dialysis with ESRD, and group A (40) healthy control. Results showed non-significant elevations in ADH levels in the patient group compared with the control group, while highly significant increase in urea, creatinine and albumin levels in in the patient group compared with the control group, also highly significant decrease in hemoglobin comparing with the control group. Also, it was observed non-significant decrease in sodium, non-significant increase in potassium and highly significant increase in chloride when comparing with the control group.

show abstract

Hyperchloremia – Why and how

Cited by 37 publications

References 28 publications

Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Biochemical recovery from exertional heat stroke follows a 16-day time course

Study of the Anti-Diuretic Hormone (ADH) on End Stage Renal Failure Disease (ESRD) Pre-Hemodialysis in Iraqi Patients

Contact Info

Product

Resources

About