Hypercarotenaemia as a symptom of weight phobiaThis study was conducted while the authors were working in the Academic Department of Psychiatry, Middlesex Hospital, London, W.1.

Crisp, A. H.; Stonehill, Edward

doi:10.1136/pgmj.43.505.721

Cited by 21 publications

(5 citation statements)

References 17 publications

(18 reference statements)

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“…AN patients commonly prefer food low in energy. Thus, fruits and vegetables may be consumed in unusually high amounts from AN patients compared to their total energy intake (11,12). Our study could not confirm this hypothesis since fruits and vegetable consumption was comparable to NW controls.…”

Section: Plasma Carotenoid Profile Of An Patients Compared To Normal Weight Femalescontrasting

confidence: 57%

“…For hypercarotenemia in AN, different mechanisms have been proposed: First, the intake of carotenoid-containing food may be relatively high compared to energy intake and other nutrients, and the carotenoid demand may be decreased (11,12). Secondly, disturbances in lipid metabolism such as hypercholesterinemia or acquired disturbances in carotenoid metabolism like impaired lipoprotein degradation and altered storage ability have been hypothesized (13,14).…”

Section: Introductionmentioning

confidence: 99%

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Hypercarotenemia in Anorexia Nervosa Patients May Influence Weight Balance: Results of a Clinical Cross-Sectional Cohort Study

et al. 2021

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Introduction: Anorexia nervosa (AN) can co-occur with hypercarotenemia, a clinical condition characterized by elevated β-carotene in plasma and skin tissue. Carotenoids have known anti-obesogenic effects in adipocyte biology. Thus, carotenoids may potentially play a retarding role in weight gain during the recovery of AN patients. This study evaluated the plasma carotenoid profile and subcutaneous adipose tissue (SAT) in a cohort of AN patients and normal weight (NW) controls.Methods: Plasma concentrations of α-carotene, β-carotene, β-cryptoxanthin, and lycopene were determined by HPLC analysis. SAT thicknesses were measured by a highly accurate and reliable ultrasound technique. Information on dietary intakes were collected by repeated 24-h recalls.Results: Sixty-two females (AN: n = 18, NW: n = 44) were included. The concentrations of β-cryptoxanthin (p = 0.045) and lycopene (p = 0.004) were significantly lower in AN patients. β-carotene levels were higher in AN patients (n.s.) and α-carotene did not differ significantly. SAT thickness was significantly lower in AN patients compared to controls (p < 0.001). β-carotene was significantly negative (rs = −0.471) and lycopene significantly positive (rs = 0.366) correlated with SAT. The correlation of β-carotene and SAT was even higher in the AN group alone (rs = −0.742). Also, β- cryptoxanthin and the sum of provitamin A carotenoids were correlated to SAT (rs = −0.647 and rs = −0.746, respectively) in AN patients. Fruits and vegetable intake did not differ significantly between AN and NW but adjusted for SAT, AN patients consumed relatively higher amounts (p = 0.006).Conclusion: Higher plasma β-carotene concentrations were associated with reduced SAT levels, most probably due to a reduced ability of the remaining adipose tissue to store carotenoids. Thus, the antiobesity effects of carotenoids might impact the treatment success of undernutrition and AN. A systemic carotenoid overload may contribute to changes in adipogenesis and metabolic capacities for energy storage. Therefore, high plasma β-carotene may be a marker of delay in weight recovery in AN patients. Interventional studies should consider including carotenoid-status in AN treatment.

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Section: Plasma Carotenoid Profile Of An Patients Compared To Normal Weight Femalescontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Hypercarotenemia in Anorexia Nervosa Patients May Influence Weight Balance: Results of a Clinical Cross-Sectional Cohort Study

et al. 2021

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“…Carotenoderma-the presence of a yellow discoloration to skin secondary to hypercarotenemia-has been described in patients with EDs since the 1960s. 65,66 Beyond its clinical appearance, carotenoderma is asymptomatic. Carotenoids are lipid-soluble compounds present in the diet that are metabolized by the intestinal mucosa and liver to the primary conversion product, retinaldehyde, which is further converted to retinol, retinyl esters, and other retinoid metabolites.…”

Section: Carotenodermamentioning

confidence: 99%

Cutaneous Signs of Malnutrition Secondary to Eating Disorders

D¹

2023

Cutis

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“…Her peripheral circulation will be relatively active. Indeed if she is near normal body weight, and especially if she has a pattern of periodic bingeing alternating with abstinence and has just binged enormously (Crisp & Stonehill, 1967), she may present acutely in a variety of ways that profoundly mask the underlying psychopathology and prompt instead investigation into primary metabolic and energy balance disorders. Thus she may deny and conceal a several days' long binge.…”

Section: Crispmentioning

confidence: 99%

Arousal, physical activity, and energy balance in eating and body weight and shape disorders

Crisp

2006

Int. J. Eat. Disord.

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Hypercarotenaemia as a symptom of weight phobiaThis study was conducted while the authors were working in the Academic Department of Psychiatry, Middlesex Hospital, London, W.1.

Cited by 21 publications

References 17 publications

Hypercarotenemia in Anorexia Nervosa Patients May Influence Weight Balance: Results of a Clinical Cross-Sectional Cohort Study

Hypercarotenemia in Anorexia Nervosa Patients May Influence Weight Balance: Results of a Clinical Cross-Sectional Cohort Study

Cutaneous Signs of Malnutrition Secondary to Eating Disorders

Arousal, physical activity, and energy balance in eating and body weight and shape disorders

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