Hypercapnic hypoxia as a rehabilitation method for patients after ischemic stroke

Alekseeva, Tatiana M.; Topuzova, Maria P.; Kulikov, Vladimir P.; Kovzelev, Pavel D.; Kosenko, Mark G.; Tregub, Pavel P.

doi:10.1080/01616412.2024.2343510

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…In this study, we therefore also included a longer-term follow-up of one month after the intervention period to assess the longer-term stability of effects on clinical symptoms and blood-based markers. Recent evidence suggests that interspersion of hypoxia with either hyperoxia or hypercapnia might respectively enable a more rapid recovery after hypoxia or enhance the potency of effect on mitochondrial metabolism, providing an opportunity for comparison to the current protocol [20,79,80]. This study includes a relatively low number of participants, which hampers its power to detect smaller treatment effects on several included standardized scales.…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trial of intermittent hypoxia in Parkinson’s disease: study rationale and protocol

Janssen Daalen,

Meinders,

Mathur

et al. 2024

BMC Neurol

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Background Parkinson’s disease (PD) is a neurodegenerative disease for which no disease-modifying therapies exist. Preclinical and clinical evidence suggest that repeated exposure to intermittent hypoxia might have short- and long-term benefits in PD. In a previous exploratory phase I trial, we demonstrated that in-clinic intermittent hypoxia exposure is safe and feasible with short-term symptomatic effects on PD symptoms. The current study aims to explore the safety, tolerability, feasibility, and net symptomatic effects of a four-week intermittent hypoxia protocol, administered at home, in individuals with PD. Methods/Design : This is a two-armed double-blinded randomized controlled trial involving 40 individuals with mild to moderate PD. Participants will receive 45 min of normobaric intermittent hypoxia (fraction of inspired oxygen 0.16 for 5 min interspersed with 5 min normoxia), 3 times a week for 4 weeks. Co-primary endpoints include nature and total number of adverse events, and a feasibility-tolerability questionnaire. Secondary endpoints include Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part II and III scores, gait tests and biomarkers indicative of hypoxic dose and neuroprotective pathway induction. Discussion This trial builds on the previous phase I trial and aims to investigate the safety, tolerability, feasibility, and net symptomatic effects of intermittent hypoxia in individuals with PD. Additionally, the study aims to explore induction of relevant neuroprotective pathways as measured in plasma. The results of this trial could provide further insight into the potential of hypoxia-based therapy as a novel treatment approach for PD. Trial registration ClinicalTrials.gov Identifier: NCT05948761 (registered June 20th, 2023).

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Section: Discussionmentioning

confidence: 99%