Hypercalcitoninaemia in patients with pheochromocytoma

Raue, Friedhelm; Bayer, J. M.; Rahn, K. H.; Herfarth, Ch.; Minne, H. W.; Ziegler, Reinhard

doi:10.1007/bf02429104

Cited by 24 publications

(8 citation statements)

References 22 publications

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“…This might be due to the possibility of early diagnosis by catecholamine screen ing, sonography, computed tomographic scan, l3lI-MIBG scintigraphy and selective venous catheterization, whereas in sporadic pheochromocytoma diagnostic procedures do not begin until clinical symptoms are present. Elevated serum calcitonin levels are not always pathognomonic for MTC in pa tients with MEN as the pheochromocytoma itself is sometimes able to secrete calcitonin [5], Adrenal medullary hyperplasia has been described [6] as a predecessor of pheochro mocytoma in MEN II. Careful clinical and laboratory screening is necessary in patients with MEN II to diagnose the pheochromocy toma before dangerous manifestations are evident.…”

Section: Discussionmentioning

confidence: 99%

Pheochromocytoma in Multiple Endocrine Neoplasia

Raue¹,

Frank²,

Meybier³

et al. 1985

Cardiology

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Three patients with a surgically confirmed and 1 with suspected pheochromocytoma as part of the syndrome of multiple endocrine neoplasia (MEN) type II are presented. Pheochromocytoma and medullary thyroid carcinoma (MTC) as well as other tumors are part of this heritable entity. Three cases were members of a MEN IIa family and 1 patient has suffered from a sporadic form of MEN IIb. Pheochromocytoma was diagnosed by screening procedures (catecholamine screening, computerized tomography, sonography or selective venous catheterization). In 2 of the patients there was no clinical manifestation of the pheochromocytoma. On three occasions MTC was diagnosed first, the thyroid tumor occurred prior to the pheochromocytoma by 7, 6, and ½ years. Pheochromocytoma occurred bilaterally in 2 patients, in 1 it is suspected in both adrenals.

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Section: Discussionmentioning

confidence: 99%

Pheochromocytoma in Multiple Endocrine Neoplasia

Raue¹,

Frank²,

Meybier³

et al. 1985

Cardiology

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“…Die parafollikulären Zellen werden dem APU D-System zugeordnet und sind bei dessen maligner Entartung in unter- (16,17). beim Karzmoid, Molanom und Phaochromozytom (18). Im Rahmen emor Nieroninsuffizienz oder als reaktive Mehrsckrotion aufgrund einer Hypcrkateämio bei Knochenmetastasen können ebenfalls Calcitoninerhohungon auftreten.…”

Section: Introductionunclassified

Die Bedeutung der radioimmunologischen Calcitoninbestimmung beim C-Zellkarzinom

Schurr¹,

Raue²,

Meybier³

et al. 1982

LaboratoriumsMedizin

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Zusammenfassung: Das C-Zellkarzinom ist durch eine Hypercalcitoninämie charakterisiert. Bei 100 Patienten mit histologisch gesicherten C-Zellkarz'momen (medulläres Schilddrüsenkarzinom) fanden sich im Serum Calcitoninspiegel (CT) zwischen 0,4 und 120ng/ml (Normbereich bis 0,3 ng l ml). Da die klinische Symptomatik häufig relativ unspezifisch ist, stellt die radioimmunologische Calcitoninbestimmung ein wesentliches präoperatives Diagnostikum dar. Der Stimulationstest für CT (i. v. Pentagastr'm) erhöht die Aussagekraft. Die Calcitoninbestimmung in mittels selektiver Venenkatheterisierung gewonnenen Blutproben ermöglicht eine Tumorlokalisation. Die radioimmunologische Bestimmung des CT hat sich bei medullären Schilddrüsenkarzinomen als Tumormarker zur Diagnosestellung und Verlaufskontrolle bewährt. Schlüsselwörter: Calcitonin -C-Zellkarzinom -Pentagastrinbelastung -selektive VenenkatheterisierungSummary: The C-cell carcinoma is characterized by high serumcalcitonin (CT) levels. In 100 patients with histological C-cell carcinoma (= medullary thyroid carcinoma = MTC) we measured CT-levels between 0.4 and 120 ngl ml (normal range up to 0.3 ngl ml). As clinical symptomatology often is unspect'fic radioimmunologicaldetermination of CT proved to be a usefulpreoperative diagnostic tool. The stimulation test (pentagastrin i. v.) improves reliability especially in cases of familiary MTC. Measuring CT in speciments gained by selective venous catheterization facilitates tumor localisation. CTjevea/ed to be a valuable tumor-marker for MTC in diagnosis and in control of follow-up.

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“…Heath and Edis (4) and others (5,6) have demonstrated still higher levels of serum calcitonin in patients with pheochromocytoma and express caution about potential confusion with multiple endocrine neoplasia, type 2. Heath and Edis (4) and others (5,6) have demonstrated still higher levels of serum calcitonin in patients with pheochromocytoma and express caution about potential confusion with multiple endocrine neoplasia, type 2.…”

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confidence: 97%

“…Elevated iCT levels are, however, found in a substantial proportion of patients with nonthyroidal tumors (2). Furthermore, there have been reports of CT-like immunoreactivity in an occasional pheochromocytoma (3)(4)(5)(6)(8)(9)(10)(11). The purpose of the present study was to examine whether pheochromocytomas commonly contained iCT-like immunoreactivity and the relationship of this finding to hypercalcitoninemia.…”

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Immunoreactive Calcitonin in Pheochromocytomas

Weinstein

Ide

1980

Experimental Biology and Medicine

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Immunoreactive calcitonin (iCT) was evaluated in serum and tumor extracts from four successive, normocalemic patients with sporadic pheochromocytoma to determine how commonly these tumors contain CT-like immunoreactivity. Levels of iCT were measured by a nonequilibrium radioimmunoassay sensitive to both the intact molecule and the 11-32 amino acid region of human CT. With this assay, iCT is detectable in 56% of normal fasting adults ( n = 52). The normal mean was 42 pg/ml with a normal range (mean k 3 SD) of undetectable to 80 pg/ml. Serial dilutions of serum from a patient with medullary carcinoma of the thyroid and of acetic acid extracts of the pheochromocytomas gave displacement curves indistinguishable from the human standard. Patient "A" had an elevated serum iCT level of 477 pg/ml. After surgery for the pheochromocytoma, his basal serum iCT was normal and there was no abnormal elevation in iCT after pentagastrin stimulation. CT-like immunoreactivity was present in each of the four tumor extracts (2500-8600 pg iCT/g wet wt) and absent from an omental lymph node removed from patient A. Hypercalcitoninerllia in patients with sporadic pheochromocytoma may not represent a concurrent medullary carcinoma of the thyroid since the presence and secretion of CT-like immunoreactivity from pheochromocytomas may be more common than previously realized.

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Hypercalcitoninaemia in patients with pheochromocytoma

Cited by 24 publications

References 22 publications

Pheochromocytoma in Multiple Endocrine Neoplasia

Pheochromocytoma in Multiple Endocrine Neoplasia

Die Bedeutung der radioimmunologischen Calcitoninbestimmung beim C-Zellkarzinom

Immunoreactive Calcitonin in Pheochromocytomas

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