Hypercalcitonemia in inhalation burn injury: A response of the pulmonary neuroendocrine cell?

Becker, Kenneth L.; O'Neil, William; Snider, Richard H.; Nylen, Eric; Moore, Charles F.; Jeng, James C.; Silva, Omega Logan; Lewis, Mark S.; Jordan, Marion H.

doi:10.1002/ar.1092360118

Cited by 27 publications

(20 citation statements)

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“…Previously, increases in serum calcitonin-like reactivities were found in patients with infections [14] or with lung disease [11,12]. However, the methods employed did not discriminate between calcitonin and procalcitonin although some of the "calcitonin-like activity" in these studies may well be attributable to increases in procalcitonin levels.…”

Section: Measurement Of Procalcitoninmentioning

confidence: 87%

“…Thus, patients who have previously undergone a total thyroidectomy can still produce high levels of procalcitonin during a severe infectious episode [9]. The exact site of procalcitonin production during sepsis is uncertain; one investigator, using katacalcin antibodies, has identified procalcitonin-like activity in human leukocytes [10], others suggest neuroendocrine cells and the lungs [11][12][13] as possible sites of production. Remarkably, the large amounts of procalcitonin produced during infections do not lead to an increase in plasma calcitonin levels or activity [9].…”

Section: Physiology Of Procalcitoninmentioning

confidence: 99%

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Procalcitonin — A new indicator of the systemic response to severe infections

et al. 1997

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Section: Measurement Of Procalcitoninmentioning

confidence: 87%

Section: Physiology Of Procalcitoninmentioning

confidence: 99%

Procalcitonin — A new indicator of the systemic response to severe infections

et al. 1997

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“…The exact site of PCT production is unknown, but the PCT producing cells seem unable to process this precursor form into the mature hormone calcitonin. Some authors have found PCT-like activity in human leukocytes, others suggest the lungs or the neuroendocrine cells as possible sites of synthesis [13][14][15]. Several cytokines are present in CSF during meningitis, where they induce endothelial-derived adhesion molecules on the cerebral blood vessels.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms responsible for the marked increase of serum PCT during systemic bacterial infections and the exact site of its production remain enigmatic [13][14][15]. In healthy volunteers PCT induction was stimulated by the intravenous application of bacterial endotoxin.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Serum and Cerebrospinal Fluid Procalcitonin Levels for the Diagnosis of Bacterial Meningitis

et al. 2001

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“…Thyroid is not the sole tissue involved in the secretion, since an infection-associated rise of PCT has been shown in a thyroidectomized patient with septicemia (2). The liver or neuroendocrine cells in the lung are possible sites of extrathyroidal PCT production in septic patients (4). Recently, it was demonstrated that PCT m-RNA is expressed by human mononuclear cells and modulated by lipopolysaccharide (LPS) and sepsis-related cytokines (5).…”

mentioning

confidence: 99%

Procalcitonin and Neopterin in Infectious Diseases

Wiedermann¹,

Innerhofer²,

Margreiter³

et al. 1999

Pteridines

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SummaryProcalcitonin, a new inflammation parameter, has been shown to be markedly increased in patients with severe bacterial and parasitic infections, septic shock, and multiple organ failure. In contrast, in severe viral infections or inflammatory reactions of non-infectious origin (e.g. toxic acute respiratory distress syndrome or toxic pancreatitis) as well as in autoimmune disorders, there is little or moderate increase of procalcitonin serum levels. Therefore procalcitonin may be used for diHerential diagnosis of bacterial versus non-bacterial inflammation. Furthermore, procaicitonin correlates with the severity of infection and sepsis and it is considered to be a valid parameter t()r monitoring both the severity and the course of sepsis and multiple organ failure as well as the success of surgical ~lI1d intensin.' therapy in critically ill patients. Neopterin production is closely associated with activation of the celluLll' immune sYstem. High neopterin levels are found in several inflamlnatory diseases and certain malignancies. ~eopterin me~lsurements are usehll for monitoring allograft recipients to detect immunological c0111plicltions. In autoimmune diseases, neopterin concentrations reflect the extent and activity of disease . In intl-crious dise~lscs, ncopterin helps in the differential diagnosis of acute viral and bacterial infections and provides prognostic intc)rmarion in human immunodeficiency virus disease and in patients with rnultiple trauma and sepsis. In this article the clinical application of procalcitonin and neopterin in infectious diseases is reyiewed, and special emphasis is given to clinical simarions in " 'hich the combined determination of both par~1l11ctcrs, neoprerin and procalcitonin, is able to suppon ditkrential diagnosis.

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Hypercalcitonemia in inhalation burn injury: A response of the pulmonary neuroendocrine cell?

Cited by 27 publications

References 0 publications

Procalcitonin — A new indicator of the systemic response to severe infections

Procalcitonin — A new indicator of the systemic response to severe infections

Predictive Value of Serum and Cerebrospinal Fluid Procalcitonin Levels for the Diagnosis of Bacterial Meningitis

Procalcitonin and Neopterin in Infectious Diseases

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