Hypercalcemia of Malignancy: Time to Pull the Brakes

Sundriyal, Deepak; Arya, Lima; Saha, Rajesh; Walia, Meenu; Nayak, Priya P

doi:10.1007/s13193-020-01131-5

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Currently, there is an urgent need for HNSCC prevention, early diagnosis and therapy. The results of a previous study demonstrated that HNSCC is closely associated with hypercalcemia ( 30 ). However, numerous members of the S100 protein family are calcium receptors, and the structure and function of their encoded proteins are regulated by Ca 2+ ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

S100 proteins in head and neck squamous cell carcinoma (Review)

Han

et al. 2023

Oncol Lett

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The most common tumor affecting the head and neck is head and neck squamous cell carcinoma (HNSCC). The characteristics of HNSCC include a rapid onset, a lack of early diagnosis, drug resistance, relapse and systemic adverse effects, leading to inadequate prevention, diagnosis and treatment. Notably, previous research suggests that there is an association between S100 proteins and HNSCC. S100A8, S100A9 and S100A14 interfere with tumor cell proliferation by blocking the cell cycle. The present review discusses this association. S100A4 enhances cancer stem cell properties, and interacts with actin and tropomyosin to promote tumor cell migration. S100A1, S100A8, S100A9, S100A10, S100A14 and S100P are involved in the initiation and progression of HNSCC via Hippo, nuclear factor κB, phosphatidylinositol kinase/protein kinase B/mammalian target of rapamycin and other signaling pathways. In addition, certain long non-coding RNAs and microRNAs are involved in regulating the expression of S100 proteins in HNSCC. Reducing the expression of certain members of the S100 protein family may enhance the chemosensitivity of HNSCC. Collectively, it is suggested that S100 proteins may function as markers and targets for the prevention, diagnosis and treatment of HNSCC.

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Section: Introductionmentioning

confidence: 99%

S100 proteins in head and neck squamous cell carcinoma (Review)

Han

et al. 2023

Oncol Lett

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“…Approximately 80% of patients with hypercalcemia in malignancy have HHM, which is caused by the ectopic secretion of parathyroid hormone-related peptide (PTHrP). Hypercalcemia in malignancy is associated with a poor prognosis, with a median survival time of 1-2 months following presentation [2,3].…”

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confidence: 99%

Recurrent distal cholangiocarcinoma and humoral hypercalcemia of malignancy: report of a rare case and literature review

et al. 2023

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A 61-year-old Japanese woman presented with epigastric pain and jaundice. Imaging showed the presence of primary distal cholangiocarcinoma (DCC). A subtotal stomach-preserving pancreaticoduodenectomy was performed, followed by chemotherapy using S-1. However, second-line chemotherapy with gemcitabine and cis-diamminedichloroplatinum was required for the treatment of hepatic metastasis of the DCC 3 months following the surgery. Nine months after the surgery, the serum calcium and parathyroid hormone-related peptide concentrations were high, at 16.5 mg/dL and 28.7 pmol/L, respectively, which suggested the presence of humoral hypercalcemia of malignancy (HHM) secondary to the DCC. Moreover, marked leukocytosis, with a white blood cell count of 40,400/μL, was also present. The patient died 11 months after the diagnosis of DCC. Because hypercalcemia of malignancy is associated with a poor prognosis, and HHM and leukocytosis caused by DCC are very rare, we have presented the present case in detail and provide a review of the existing literature.

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S100 proteins in head and neck squamous cell carcinoma

Han

et al. 2022

Preprint

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The most common tumor affecting the head and neck is head and neck squamous cell carcinoma (HNSCC). Characteristics of HNSCC include rapid onset, a lack of early diagnosis, drug resistance, relapse and systemic adverse effects, leading to inadequate prevention, diagnosis and treatment. Notably, previous research suggests that there is an association between S100 proteins and HNSCC. S100A8, S100A9 and S100A14 interfere with tumor cell proliferation by blocking the cell cycle. S100A4 enhances cancer stem cell properties, and interacts with actin and tropomyosin to promote tumor cell migration. S100A1, S100A8, S100A9, S100A10, S100A14 and S100P are involved in the occurrence and development of HNSCC via Hippo, nuclear factor κB, phosphatidylinositol kinase/protein kinase B/mammalian target of rapamycin and other signaling pathways. In addition, certain long non-coding RNAs (lncRNAs) and microRNAs are involved in regulating the expression of S100 proteins in HNSCC. Reducing the expression of certain members of the S100 protein family may improve the chemosensitivity of HNSCC. Collectively, these results suggested that S100 proteins may act as markers and targets for the prevention, diagnosis and treatment of HNSCC.

show abstract

Hypercalcemia of Malignancy: Time to Pull the Brakes

Cited by 3 publications

References 9 publications

S100 proteins in head and neck squamous cell carcinoma (Review)

S100 proteins in head and neck squamous cell carcinoma (Review)

Recurrent distal cholangiocarcinoma and humoral hypercalcemia of malignancy: report of a rare case and literature review

S100 proteins in head and neck squamous cell carcinoma

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