Abstract:Objective: Hypercalcemia of malignancy (HCM) is caused by 1 of 5 known mechanisms including systemic release of ectopic parathyroid hormone (PTH)-related protein (PTHrP), calcitriol, PTH, cytokines, or destruction of bone by osteolytic metastases. We report the first case of 2 simultaneous mechanisms for HCM in a patient with a peripheral nerve sheath tumor (PNST) Methods: PubMed and Google Scholar searches were performed using “hypercalcemia of malignancy” as the search term. Results: A 26-year-old woman wi… Show more
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