Hypercalcemia in Inpatient Setting: Diagnostic Approach and Management

Minhas, Parminder; Virdi, Jaspreet

doi:10.1007/s40138-017-0126-5

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…The calcitonin (CT), Class B1 GPCRs (CTRs), are highly expressed on osteoclasts and have been exploited therapeutically for treatment of bone disorders, including Paget’s disease, hypercalcemia of malignancy and osteoporosis [2] , [3] , [4] , [5] . The receptors are also expressed in numerous other cells and tissues including leucocytes and their precursors, the central nervous system, kidney, lung, gastrointestinal tract and reproductive tissues [6] , thereby influencing pain perception, feeding and reproduction, and ion secretion [2] , [7] , though these actions are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Maso

Zhu

Pham

et al. 2018

Biochemical Pharmacology

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Section: Introductionmentioning

confidence: 99%

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Maso

Zhu

Pham

et al. 2018

Biochemical Pharmacology

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“…to PHPT and conditions that mimic PHPT as familial hypocalciuric hypercalcemia (FHH) 1,3 . Other conditions such as malignancy, vitamin D toxicity, granulomatous disorders, or multiple myeloma were excluded as the patient had elevated intact PTH with normal vitamin D levels and normal renal function 15 . FHH suspicion was low in our patient as other family members did not show any history of urolithiasis or hypercalcemia, and urine calcium excretion was greater than 200 mg daily 15 .…”

Section: Pth-dependent Hypercalcemia Narrows Possible Differential Di...mentioning

confidence: 99%

Bilateral Staghorn Calculi and Urosepsis as Uncommon Presentations of Primary Hyperparathyroidism

Luna-Ceron,

Muthineni,

Massebo

et al. 2024

Preprint

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Background Primary hyperparathyroidism (PHPT) is a prevalent endocrine disorder characterized by excessive parathyroid hormone (PTH) secretion, traditionally associated with hypercalcemia and consequential skeletal and renal complications. While the typical manifestations of PHPT are well-documented, instances of its co-occurrence with bilateral staghorn calculi are infrequently reported. Case presentation: We present the case of a 64-year-old Hispanic female who presented with abdominal pain and sepsis. Subsequent investigations revealed bilateral staghorn calculi on abdominal computed tomography. Metabolic profiling demonstrated hypercalcemia (10.8 mmol/L), elevated intact PTH levels (132.3 pg/mL), normal phosphorus (2.6 mmol/L), and vitamin D levels (43.5 IU). Urinary cultures isolated extended spectrum beta-lactamase (ESBL) E. coli, and seven days of Ertapenem was administered. Suspecting PHPT, a parathyroid 14-sestamibi single photon emission computed tomography (SPECT) was performed, disclosing a 6 mm right inferior parathyroid mass indicative of a parathyroid adenoma. Initiation of Cinacalcet therapy resulted in a prompt decline in serum calcium levels within 48 hours. The patient was planned for surgical intervention involving parathyroidectomy and bilateral nephrolithotomy. Conclusions This case highlights the importance of comprehensive metabolic evaluation for patients presenting with bilateral staghorn calculi, emphasizes the need for a timely and tailored approach to urological and endocrinological management.

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Hypercalcemia in Inpatient Setting: Diagnostic Approach and Management

Cited by 2 publications

References 13 publications

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Bilateral Staghorn Calculi and Urosepsis as Uncommon Presentations of Primary Hyperparathyroidism

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