Hypercalcemia associated with extracorporeal life support in neonates

Fridriksson, Jon H.; Helmrath, Michael A.; Wessel, Jacqueline; Warner, Brad W.

doi:10.1053/jpsu.2001.21608

Cited by 19 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another consideration is that of heparin-induced osteoclastic bone resorption, given her prolonged time on ECMO, requiring extended therapeutic anticoagulation with heparin. Hypercalcaemia is a well-documented complication of prolonged ECMO support in both neonatal and paediatric populations but has not been described in adults on prolonged ECMO support [27,28]. The hypercalcemia in our patient was attributed to prolonged bed rest and immobilisation, resulting in excessive bone resorption.…”

Section: Discussionmentioning

confidence: 59%

The Prolonged Use of VV ECMO Support in COVID-19: A Case Report

Fitzgerald

Vachharajani

Davidson

et al. 2020

The Journal of Critical Care Medicine

View full text Add to dashboard Cite

COVID-19 has resulted in unprecedented global health and economic challenges. The reported mortality in patients with COVID-19 requiring mechanical ventilation is high. VV ECMO may serve as a lifesaving rescue therapy for a minority of patients with COVID-19; however, its impact on overall survival of these patients is unknown. To date, few reports describe successful discharge from ECMO in COVID-19 after a prolonged ECMO run. The only Australian case of a COVID-19 patient, supported by prolonged VV ECMO in conjunction with prone ventilation, complicated by significant airway bleeding, and successfully decannulated after forty-two days, is described. VV ECMO is a resource-intense form of respiratory support. Providing complex therapies such as VV ECMO during a pandemic has its unique challenges. This case report provides a unique insight into the potential clinical sequelae of COVID-19, supported in an intensive care environment which was not resource-limited at the time, and adds to the evolving experience of prolonged VV ECMO support for ARDS with a goal to lung recovery.

show abstract

Section: Discussionmentioning

confidence: 59%

The Prolonged Use of VV ECMO Support in COVID-19: A Case Report

Fitzgerald

Vachharajani

Davidson

et al. 2020

The Journal of Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…In addition to cellular activation and damage, ECMO also causes biochemical changes. A frequent problem at initiation of ECMO is hypercalcaemia (serum Ca > 11 mg ⁄ dl; > 2.74 mmol ⁄ l) affecting approximately one-third of neonates and associated with longer ECMO support and more platelet transfusions [16].…”

Section: Technical Aspects Of Extracorporeal Circuitsmentioning

confidence: 99%

Blood transfusions in neonatal cardiac surgery and ECMO

Brand

2009

ISBT Science Series

View full text Add to dashboard Cite

“…Calcium homeostasis disturbances in neonates under ECMO have first been suspected in 2001 by Fridriksson, who described hypercalcemia during ECMO in neonates. [ 5 ] In these patients, hypercalcemia was associated with an increased mortality and longer duration of ECMO. In 2005, Hak reported an increase of PTH levels and a decrease of calcitriol during neonatal ECMO.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 4 ] However, previous studies also describe recurrent metabolic disturbances such as calcium homeostasis dysregulation. [ 5 6 ] The mechanism of these abnormalities remains unclear, but severe consequences of hypercalcemia with nephrocalcinosis are anecdotally observed in surviving children. [ 7 8 ] The aim of this study was to confirm and precise calcium homeostasis disturbances during neonatal ECMO.…”

Section: Introductionmentioning

confidence: 99%

Calcium homeostasis disorder during and after neonatal extracorporeal membrane oxygenation

Rambaud¹,

Guellec²,

Guilbert³

et al. 2015

Indian Journal of Critical Care Medicine

View full text Add to dashboard Cite

Background and Aims:Extracorporeal membrane oxygenation (ECMO) is used during pediatric resuscitation in case of refractory hypoxemia or septic shock under maximum therapy. Previous studies describe calcium homeostasis dysregulation. The aim of this study was to confirmed of calcium homeostasis dysregulation in neonates under ECMO and supposed news explanation.Subjects and Methods:From November 2012 to July 2013, we performed a prospective single center observational study. Eleven neonatal patients were included. Blood was obtained before and during ECMO (day 7, 14 and 21) for parathyroid hormone (PTH), protein adjusted serum calcium, ionized calcium, magnesium, and calcitriol levels. All surviving patients underwent a consultation up to 6 months after ECMO weaning.Results:During ECMO PTH was inadequately high with normal serum calcium on day 7 (PTH: 73.54 ± 40 ng/l; calcemia: 2.33 ± 0.21 mmol/l), day 14 (PTH: 57.63 ± 29.57 ng/l; calcemia: 2.44 ± 0.43 mmol/l) and day 21 (PTH: 54.93 ± 8.43 ng/l; calcemia: 2.13 ± 0.09 mmol/l). The absence of correlation between serum calcium and PTH levels seem to confirm the dysregulation of PTH - serum calcium metabolism during ECMO. Six months after ECMO weaning, we noticed hypercalcemia with normal PTH.Conclusions:We confirmed the existence of severe disturbances of calcium homeostasis in neonates on ECMO and supposed the possible damage of calcium regulation. We did not succeed in finding clear explanations of these disturbances.

show abstract

Hypercalcemia associated with extracorporeal life support in neonates

Cited by 19 publications

References 21 publications

The Prolonged Use of VV ECMO Support in COVID-19: A Case Report

The Prolonged Use of VV ECMO Support in COVID-19: A Case Report

Blood transfusions in neonatal cardiac surgery and ECMO

Calcium homeostasis disorder during and after neonatal extracorporeal membrane oxygenation

Contact Info

Product

Resources

About