Hypercalcemia-Associated Posterior Reversible Encephalopathy Syndrome

Mirian, Ario; Le, Christine; Sharma, Manas; Budhram, Adrian; Markovic, Nevena

doi:10.1177/19418744211000974

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…With regard to the 51-year-old woman with PRES-related hypercalcemia described in the Case Report, we agree with authors’ insight that there are various possible causes of the neurological symptom of high-level serum calcium. In a similar Case Report by Mirian et al [ 2 ], a 74-year-old woman with PRES is described with elevations in serum calcium associated with this syndrome; her imaging abnormalities completely resolved after the serum calcium returned to normal. There is also the case of a 38-year-old woman with breast tumor reported by Camara-Lemarroy et al [ 3 ]; for this patient, the treating physicians considered the physiopathological mechanisms of malignant hypercalcemia (14.5 mg/dL) that can lead to neurological symptoms corresponding to PRES.…”

Section: To the Editormentioning

confidence: 74%

Comment on “Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer: A case report”

Kunić¹,

Ibrahimagić²,

Kojic³

et al. 2022

WJCC

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Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic encephalopathic state, manifesting clinical symptoms of headache, altered consciousness, visual disturbances, and seizures. Although several diseases have been identified as causative of PRES, the underlying mechanism remains unclear. Song et al recently published “Posterior reversible encephalopathy syndrome (PRES) in a patient with metastatic breast cancer: A case report“ in the World Journal of Clinical Cases , highlighting and discussing the role of hypercalcemia in PRES as related to uncontrolled hypertension. To build upon this case description, we provide further insight into the possible underlying mechanisms of PRES through this commentary.

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Section: To the Editormentioning

confidence: 74%

Comment on “Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer: A case report”

Kunić¹,

Ibrahimagić²,

Kojic³

et al. 2022

WJCC

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“…Hypercalcemia-induced PRES is rare, and a few cases of PRES triggered by hypercalcemia have been reported. We have tabulated the reported cases of hypercalcemia-induced PRES in Table 2 [ 5 - 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several diseases have been reported to increase the risk of developing PRES, such as hypertension, chronic kidney disease, and preeclampsia, and chemotherapeutic drugs have also been reported to be associated with PRES [ 3 , 4 ]. PRES induced by hypercalcemia is uncommon and not widely underlined in the literature [ 5 - 10 ]. We highlight a case of malignant hypercalcemia-induced PRES in a female patient diagnosed with advanced breast carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Malignant Hypercalcemia: A Rare Etiology of Posterior Reversible Encephalopathy Syndrome

Odoma,

Zahedi,

Haq

et al. 2023

Cureus

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Posterior reversible encephalopathy syndrome (PRES) is a rare and severe neurotoxic encephalopathic state characterized by variable neurologic manifestations ranging from headache and confusion to seizures, coma, and reversible subcortical vasogenic edema on imaging. PRES is commonly induced by chronic renal failure, hypertension, chemotherapeutic drugs, and eclampsia. PRES induced by hypercalcemia is uncommon and not widely underlined in the literature. We underline a case of a 61-year-old female diagnosed with advanced breast carcinoma presented with altered sensorium and generalized limb weakness. She was found to have malignant hypercalcemia, and brain imaging demonstrated subcortical vasogenic edema in the occipital and frontal lobe, suggestive of PRES. Her condition gradually improved after the treatment of hypercalcemia.

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Hypercalcemia-Associated Posterior Reversible Encephalopathy Syndrome

Cited by 2 publications

References 4 publications

Comment on “Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer: A case report”

Comment on “Posterior reversible encephalopathy syndrome in a patient with metastatic breast cancer: A case report”

Malignant Hypercalcemia: A Rare Etiology of Posterior Reversible Encephalopathy Syndrome

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