Hypercalcemia and gastric secretion in man.

Murphy, D L; Goldstein, H. H.; Boyle, J D; Ward, S

doi:10.1152/jappl.1966.21.5.1607

Cited by 52 publications

(8 citation statements)

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“…In every subject studied, except in the special circumstances discussed below, intravenous administration of calcium, either as gluconate or chloride, led to a rise in the output of acid and pepsin above the resting secretion. This result agrees with the findings of most previous authors (Donegan and Spiro, 1960; Barreras and Donaldson, 1966;Sereghy and Gyurkovich, 1927;Ottenjann et al, 1963;Fillastre et al, 1963;Murphy et al, 1966), but not those of Fikry and Dorry (1964), who found that calcium inhibited both basal and histamine-stimulated secretion. Fikry and Dorry administered calcium by repeated intravenous injections, in doses equivalent to 40 ml.…”

Section: Effect Of Vagotomy and Cholecystectomy On The Gastric Secretsupporting

confidence: 93%

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Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

Smallwood¹

1967

Gut

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Section: Effect Of Vagotomy and Cholecystectomy On The Gastric Secretsupporting

confidence: 93%

“…Widmaier, and Demling, 1963;Fillastre, Blaise, Bernier, and Richet, 1963;Murphy, Goldstein, Boyle, and Ward, 1966). However, a detailed examination of the pattern of rise and fall of serum calcium and gastric secretion has not been made.…”

mentioning

confidence: 99%

Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

Smallwood¹

1967

Gut

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“…Other possible effects of calcium on gastric secretion include activation or release of cyclic-AMP, which may be the second messenger in gastrinstimulated gastric secretion (Sutherland, Hardman, Butcher, and Broadus, 1969;Sutherland and Robison, 1966), increased blood flow (Donegan and Spiro, 1960), or a local cholinergic effect or acetylcholine release (Murphy, Goldstein, Boyle, and Ward, 1966). In conclusion, the release of antral gastrin seems to be a necessary condition for calcium to induce gastric acid secretion in man.…”

Section: Discussionmentioning

confidence: 99%

The effect of calcium on gastric acid and gastrin secretion in antrectomized subjects

Christiansen¹,

Rehfeld²,

Stadil³

1974

Gut

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SUMMARY Serum gastrin concentrations and gastric acid secretion were measured in nine antrectomized subjects during infusion of saline and calcium gluconate. The basal gastrin level was of the same magnitude as in normal individuals and unoperated duodenal ulcer patients. Calcium infusion only induced gastrin release in one patient and did not induce acid secretion in any of the patients.The intravenous infusion of calcium stimulates gastric acid secretion in normal individuals (Reeder, Jackson, Ban, Clendinnen, Davidson, and Thompson, 1970) and in duodenal ulcer patients (Barreras and Donaldson, 1967 (Christiansen and Hendel, 1972).Studies by Reeder et al (1970) support the view that calcium exerts its effect on gastric acid secretion through the release of gastrin. Rosato, Mullen, Lanciault, Rosato, and Brooks (1973), who in conscious monkeys also found reproducible elevations in serum gastrin concentrations after calcium infusion, could not, however, demonstrate any correlation between serum gastrin concentration and gastric acid secretion.Further information on any relationship between calcium concentration and gastrin stimulation of acid secretion could be found by studying the effect of an infusion of calcium salts on the gastric acid secretion in patients in whom the antral source of gastrin had been removed. Material and MethodsNine patients were studied, eight men and one woman, ages ranging from 22 to 60 years, who had had an antrectomy for duodenal or prepyloric ulcer

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“…The stimulation of gastric acid secretion in man in response to intravenous infusion of calcium has been reported by several investigators (Donegan and Spiro, 1960;Fillastre, Blaise, Bernier, and Richet, 1963;Murphy, Goldstein, Boyle, and Ward, 1966;Barreras and Donaldson, 1967). The magnitude of the calcium-induced acid secretion in duodenal ulcer patients amounts to approximately 30 % of the maximum response to betazole hydrochloride (Murpby et al, 1966; Barreras and Donaldson, 1967).…”

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confidence: 91%

Interaction of calcium and pentagastrin on gastric acid secretion in man

Christiansen¹,

Hendel²

1972

Gut

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SUMMARY In a recent report based on the study of a single human subject calcium was found to potentiate the action of pentagastrin on gastric acid secretion.To elucidate this problem gastric acid secretion was studied in five patients during stimulation with pentagastrin and during stimulation with pentagastrin and calcium. No potentiation between the two agents was found.The stimulation of gastric acid secretion in man in response to intravenous infusion of calcium has been reported by several investigators (Donegan and Spiro, 1960;Fillastre, Blaise, Bernier, and Richet, 1963;Murphy, Goldstein, Boyle, and Ward, 1966;Barreras and Donaldson, 1967). The magnitude of the calcium-induced acid secretion in duodenal ulcer patients amounts to approximately 30 % of the maximum response to betazole hydrochloride (Murpby et al, 1966;Barreras and Donaldson, 1967 Grossman, 1972). It has also been shown. however, that calcium infusion can produce increased acid secretion in patients who have had a truncal vagotomy and antrectomy which suggests a direct stimulation of the parietal cells (Basso and Passaro, 1970).This observation renders probable that the interaction of calcium and gastrin consists not only in a release of gastrin but also in a potentiation of gastrin by calcium. Basso and Passaro (1970) actually found that calcium potentiates the action of pentagastrin on acid secretion in ferrets, and the study of a single human subject also showed that potentiation occurred.The motive for the present study has been a more thorough investigation of this latter observation. Materials and MethodsThe material comprises five patients, two men and

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Hypercalcemia and gastric secretion in man.

Cited by 52 publications

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Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

The effect of calcium on gastric acid and gastrin secretion in antrectomized subjects

Interaction of calcium and pentagastrin on gastric acid secretion in man

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