Hypercalcaemic Osteomalacia Due to Aluminium Toxicity

Boyce, B.F.; Elder, H. Y.; Elliot, Heidi; Fogelman, Ignac; Fell, G. S.; Junor, B. J. R.; Beastall, G. H.; Boyle, I.T.

doi:10.1016/s0140-6736(82)90049-6

Cited by 154 publications

(52 citation statements)

References 18 publications

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“…These findings in cortical bone differ from those of two previous reports, both of which indicated that rats with renal insufficiency given repeated injections of aluminum chloride in daily dosages comparable to those used in the present study develop osteomalacia in trabecular bone (13,14). The duration of aluminum administration in the present study was 4 wk, whereas previous investigations have been [8][9][10][11][12][13][14][15] wk in length (12)(13)(14). This shorter time interval was chosen to examine the early effects of aluminum administration on bone.…”

Section: Discussioncontrasting

confidence: 99%

“…A feature common to both clinical and experimental evaluations of aluminum-associated osteomalacia has been a low rate of bone formation as measured by double tetracycline labeling (6)(7)(8)14). The present results confirm this observation.…”

Section: Discussionsupporting

confidence: 86%

“…Aluminum accumulation in bone may be a factor in the pathogenesis of dialysis-associated osteomalacia (1)(2)(3)(4)(5)(6)(7)(8). The aluminum content ofbone has been shown to be increased by both chemical and histochemical techniques in some patients undergoing hemodialysis, a substantial portion of whom show histologic evidence of osteomalacia on bone biopsy (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

“…The aluminum content ofbone has been shown to be increased by both chemical and histochemical techniques in some patients undergoing hemodialysis, a substantial portion of whom show histologic evidence of osteomalacia on bone biopsy (6)(7)(8)(9). The severity of osteomalacia in these patients, assessed by quantitative histomorphometry, correlates positively with the content of aluminum in bone (9).…”

Section: Introductionmentioning

confidence: 99%

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Short-term aluminum administration in the rat. Effects on bone formation and relationship to renal osteomalacia.

Goodman¹,

Gilligan²,

Horst³

1984

J. Clin. Invest.

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Abstract. Aluminum may be pathogenic in the osteomalacia observed in some patients receiving hemodialysis. To study the early effects ofAl on bone growth, bone formation, mineralization, and resorption were measured during short-term Al exposure in the tibial cortex of pair-fed control (C, n = 10), aluminum-treated (AL, n = 9), subtotally nephrectomized control (NX-C, n = 7), and subtotally nephrectomized aluminum-treated (NX-AL, n = 8) rats using double tetracycline labeling of bone. Animals received 2 mg/d of elemental Al intraperitoneally for 5 d/wk over 4 wk. Total bone and matrix (osteoid) formation, periosteal bone and matrix formation, and periosteal bone and matrix apposition fell by 20% in AL from C, P < 0.05 for all values, and by 40% in NX-AL from NX-C, P < 0.01 for all values. Moreover, each measurement was significantly less in NX-AL than in AL, P < 0.05 for all values. Osteoid width did not increase following aluminum administration in either AL or NX-AL. Resorption surface increased from control values in both AL and NX-AL; also, resorptive activity at the endosteum was greater in NX-AL than in NX-C, P < 0.05. Thus, aluminum impairs new bone and matrix formation but does not cause classic osteomalacia in the cortical bone of rats whether renal function is normal or reduced. These findings may represent either a different response to aluminum administration in cortical bone as contrasted to trabecular bone or an early phase in the development of osteomalacia.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Short-term aluminum administration in the rat. Effects on bone formation and relationship to renal osteomalacia.

Goodman¹,

Gilligan²,

Horst³

1984

J. Clin. Invest.

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“…chains by Al 3þ ); however, as aluminium is a known neurotoxin [20] and also negatively affects bone mineralization [21][22][23], dental GPCs are not ideal for orthopaedic applications. Efforts have been made to replace aluminium with iron [24] or zinc [25]; however, these also have drawbacks and particularly too high a zinc release has been shown to result in cytotoxic reactions [26].…”

Section: Discussionmentioning

confidence: 99%

Bactericidal strontium-releasing injectable bone cements based on bioactive glasses

Brauer

Karpukhina

Kedia

et al. 2013

J. R. Soc. Interface.

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Strontium-releasing injectable bone cements may have the potential to prevent implant-related infections through the bactericidal action of strontium, while enhancing bone formation in patients suffering from osteoporosis. A meltderived bioactive glass (BG) series (SiO 2 -CaO-CaF 2 -MgO) with 0-50% of calcium substituted with strontium on a molar base were produced. By mixing glass powder, poly(acrylic acid) and water, cements were obtained which can be delivered by injection and set in situ, giving compressive strength of up to 35 MPa. Strontium release was dependent on BG composition with increasing strontium substitution resulting in higher concentrations in the medium. Bactericidal effects were tested on Staphylococcus aureus and Streptococcus faecalis; cell counts were reduced by up to three orders of magnitude over 6 days. Results show that bactericidal action can be increased through BG strontium substitution, allowing for the design of novel antimicrobial and bone enhancing cements for use in vertebroplasty or kyphoplasty for treating osteoporosis-related vertebral compression fractures.

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Aluminium [MAK Value Documentation in German language, 1987]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 12. Lieferung, Ausgabe 1987 Der Artikel enthält folgende Kapitel: Vorkommen, Herstellung und Verwendung Allgemeiner Wirkungscharakter Zusammenfassende toxikologische Bewertung Problematik der analytischen Bestimmung von Aluminium Chemisches Verhalten von Aluminium im biologischen System Aufnahme, Verteilung und Ausscheidung von Aluminium beim Menschen Spezifische Wirkungen von Aluminium im Organismus Erfahrungen beim Menschen Berufliche Erkrankungen durch Aerosole des Aluminiums und seiner Verbindungen Beschaffenheit von Aluminiumpartikeln und ihr Einfluß auf die Ätiologie der Aluminose Staubmessungen in Aluminiumbetrieben Aluminiumspiegel im Blutplasma und Urin Zur Frage einer krebserzeugenden Wirkung von Aluminium Tierexperimentelle Untersuchungen Begründung des MAK‐Wertes für Aluminium, seine oxidischen und hydroxidischen Verbindungen

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Hypercalcaemic Osteomalacia Due to Aluminium Toxicity

Cited by 154 publications

References 18 publications

Short-term aluminum administration in the rat. Effects on bone formation and relationship to renal osteomalacia.

Short-term aluminum administration in the rat. Effects on bone formation and relationship to renal osteomalacia.

Bactericidal strontium-releasing injectable bone cements based on bioactive glasses

Aluminium [MAK Value Documentation in German language, 1987]

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