Hypercalc�mie bei malignen Erkrankungen

Heidbreder, E.; Schafferhans, K; Heidland, A.

doi:10.1007/bf01496721

Cited by 4 publications

(2 citation statements)

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“…Key words: Hypercalcaemia -lymphocytic leukaemia -Non-Hodgkin-Lymphoma -Osteoclasts activating Factor (OAF) Wfihrend eine Hypercalcfimie beim Myelom relativ h/iufig anzutreffen ist, findet sic sich bei anderen h/imatologischen Systemkrankheiten selten [8,10].…”

Section: Hypercalcaemia In Chronic Lymphocytic Leukaemia and Other Nounclassified

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Hypercalcämien bei chronisch lymphatischen Leukämien und anderen Non-Hodgkin-Lymphomen

et al. 1987

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Three years after diagnosis of chronic lymphocytic leukaemia in a 57 year old man developed a hypercalcaemia with multiple bone fractures, concomitant an increase of activity of the leukaemia. There was no hyperparathyroidism, nor in serum, nor inside the lymphocytes. The osteopenia was caused by leukaemic infiltrations. An additional activation of osteoclasts was caused by an osteoclasts activating factor (OAF), produced by the leukaemic cells. 2 (= 2.25%) of 89 Non-Hodgkin-Lymphomas except chronic lymphatic leukaemia had a moderate hypercalcaemia with concomitant activation of the underlying disease. 9 (= 7.7%) of 116 chronic lymphocytic leukaemias had hypercalcaemia, 2 thereof with increased activity of the leukaemia. Hypercalcaemia is thus very rarely found in other Non-Hodgkin-Lymphomas, in chronic lymphocytic leukaemia some what more often, and only here a concomitant increase in the activity of the underlying disease could be observed in some cases.

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Section: Hypercalcaemia In Chronic Lymphocytic Leukaemia and Other Nounclassified

“…Dieser kann als Produkt der aktivierten B-Lymphozyten aufgefaf3t werden [8], m6glicherweise aber auch der reaktiven T-Zell-Population innerhalb der Neoplasie [2 a]. das 1.25-Dihydroxy-Vitamin D. Auch eine Parathormon-fihnliche Substanz konnte im Serum ausgeschlossen werden.…”

Section: Diskussionunclassified