Hyperbranched polyselenides as glutathione peroxidase mimics

Abstract

Novel hyperbranched polyselenides with multi-catalytic sites at the branching units have been synthesized which may provide a new approach towards glutathione peroxidase mimics.

Fully‐Branched Hyperbranched Polymers with a Diselenide Core as Glutathione Peroxidase Mimics

“…The catalytically active center of GPx, selenocysteine, is located in the hydrophobic cavity of the protein surface 25. Inspired by the structure of native GPx, one of the strategies to design GPx mimics with high efficiency is to consider the substrate binding and mimic the catalytic hydrophobic environment 26–34. Previously we have prepared a dendrimer‐based GPx mimic with a diselenide core that makes full use of the microenvironment governed by the delicate molecular architecture 35.…”

Design of Artificial Selenoenzymes Based on Macromolecular Scaffolds

“…A hyperbranched polyselenide with multi‐catalytic sites at the branching units as a novel GPx model was synthesized using NaHSe (as the AA' monomer) and 1,3,5‐tris(bromomethyl)‐2,4,6‐trimethylbenzene [as the B 3 monomer, Figure 5(A)]. 66 In comparison with other enzyme models, the multi‐catalytic sites provide a good environment for the substrate and give a proper position to catalytic sites, and then enhance the catalytic activity. To increase water solubility of the enzyme model, oligo(ethylene oxide) groups were incorporated to the periphery of hyperbranched polyselenide.…”

A new selenium-based RAFT agent for surface-initiated RAFT polymerization of 4-vinylpyridine

“…They [24] also reported the RAFT polymerization of styrene using the similar phosphinodiselenoic esters under UV irradiation. Zhang et al [26] have synthesized a new hyperbranched polyselenide with multicatalytic sites at the branching units which acts as a new glutathione peroxidase mimic. Considering that selenium is an indispensable element in human body, the introduction of selenium into polymer chains have been used as bio-related materials in biological applications [27e30].…”