Hyperbranched polymer hydrogels with large stimuli-responsive changes in storage moduli and peroxide-induced healing

Chimala, Prathyusha; Perera, M. Mario; Wade, Aissatou; McKenzie, Tucker J.; Allor, Joshua; Ayres, Neil

doi:10.1039/d1py00560j

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Polym. Chem.

2021

DOI: 10.1039/d1py00560j

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Hyperbranched polymer hydrogels with large stimuli-responsive changes in storage moduli and peroxide-induced healing

Prathyusha Chimala

M. Mario Perera

Aissatou Wade

et al.

Abstract: Hydrogels with the ability to repair damage or undergo controllable changes in stiffness and swelling are becoming increasingly important in multiple technologies. For example, hydrogels performing as dynamic matrices are...

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Cited by 3 publications

References 63 publications

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Modulation der Steifigkeit und Pulsierende Freisetzung in Dual‐Responsiven Hydrogelen

Jain,

Trapani,

Trappmann

et al. 2024

Angewandte Chemie

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Inspired by nature, self‐regulation can be introduced in synthetic hydrogels by incorporating chemo‐mechanical signals or coupled chemical reactions to maintain or adapt the material’s physio‐chemical properties when exposed to external triggers. In this work, we present redox and light dual stimuli responsive hydrogels capable of rapidly adapting the polymer crosslinking network while maintaining hydrogel stability. Upon irradiation with UV light, polymer hydrogels containing redox responsive disulfide crosslinks and light responsive ortho‐nitrobenzyl moieties show a release of payload accompanied by adaptation of the hydrogel network towards higher stiffness due to in situ crosslinking by S‐nitrosylation. Whereas the hydrogel design allows the network to either become softer in presence of reducing agent glutathione or stiffer upon UV irradiation, simultaneous application of both stimuli induces network self‐regulation resulting in a pulsatile form of payload release from the hydrogel. Finally, adaptive stiffness was used to make tunable hydrogels as substrates for different cell lines.

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Modulation der Steifigkeit und Pulsierende Freisetzung in Dual‐Responsiven Hydrogelen

Jain,

Trapani,

Trappmann

et al. 2024

Angewandte Chemie

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Stiffness Modulation and Pulsatile Release in Dual Responsive Hydrogels

Jain,

Trapani,

Trappmann

et al. 2024

Angew Chem Int Ed

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Fabrication of pH and thermal dual-responsive hyperbranched copolymer grafted magnetic graphene oxide via surface-initiated RAFT-SCVP for controlled release of DOX

Kohestanian

Keshavarzi

Pourjavadi

et al. 2023

Materials Today Communications

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Hyperbranched polymer hydrogels with large stimuli-responsive changes in storage moduli and peroxide-induced healing

Abstract: Hydrogels with the ability to repair damage or undergo controllable changes in stiffness and swelling are becoming increasingly important in multiple technologies. For example, hydrogels performing as dynamic matrices are...

Cited by 3 publications

References 63 publications

Modulation der Steifigkeit und Pulsierende Freisetzung in Dual‐Responsiven Hydrogelen

Modulation der Steifigkeit und Pulsierende Freisetzung in Dual‐Responsiven Hydrogelen

Stiffness Modulation and Pulsatile Release in Dual Responsive Hydrogels

Fabrication of pH and thermal dual-responsive hyperbranched copolymer grafted magnetic graphene oxide via surface-initiated RAFT-SCVP for controlled release of DOX

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