Hyperbranched Polyether Polyols with Liquid Crystalline Properties

Abstract

The attachment of mesogens as end groups to hyperbranched polyglycerol (degree of polymerization 22-45; see schematic representation, the rigid mesogens are shown as rods and the flexible alkyl chains as lines) leads to liquid crystalline polymers with narrow polydispersity, whose liquid crystalline behavior is induced by the mesogenic end groups only.

Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate

“…This has led to the exploration of innumerable natural as well as synthetic materials, and as a consequence drug delivery has evolved from mere dispensing of elixirs and solutions to the state-of-the art technology with exquisitely tailored nano-delivery systems. In turn, this has resulted in the meticulous development of advanced nanoscale materials such as cross-linked nanoparticles [1,2], hyperbranched polymers [3,4], dendrimers [4,5], etc. with the properties desirable for drug therapy.…”

Synthesis and characterization of hyperbranched polyglycerol hydrogels

“…These treelike structures were until recently regarded as poorly defined compared to the perfectly structured dendrimers due to their broad molecular weight distribution and random branching. However, recently novel synthetic methods were developed in which substantially betterdefined hyperbranched polymers with low molecular weight distributions were obtained [1,3,[6][7][8]. As an example, the anionic ring-opening multibranching polymerization (ROMBP) [1,2,6,9] of glycidol resulted in hyperbranched polyglycerol (HyPG).…”

“…This structural feature resembles the wellknown poly(ethylene glycol) (PEG) that is accepted for various biomedical applications [11][12][13][14][15]. The polyetherbackbone of HyPG, taking the biocompatibility of aliphatic polyether structures such as PEG into account, makes HyPG an attractive polymer for biomedical and pharmaceutical applications [4][5][6][7][8][9]. Additionally, the hydrophilicity in combination with its hydroxyl functionalities makes HyPG very suitable for the design of hydrogels.…”

A Novel Micellar PEGylated Hyperbranched Polyester as a Prospective Drug Delivery System for Paclitaxel

“…Surface functionalization of symmetric dendrimeric1–11 and non‐symmetric hyperbranched polymers,12–20 collectively known as dendritic polymers, has proven a fruitful strategy for preparing diversified materials including systems for drug delivery 21–31. The application of dendritic polymers as drug carriers is an outcome of their structural architecture.…”