Hyperbranched Polycarbonate‐Based Multimolecular Micelle with Enhanced Stability and Loading Efficiency

Abstract

We herein develop a facile catalyst-free method to prepare hyperbranched hydroxyl-enriched aliphatic polycarbonate according to SCROP strategy. PEG-attached multiarm hyperbranched copolymer HEHDO-star-mPEG was further designed. It was found that HEHDO-star-mPEG can self-assemble into supramolecular multimolecular micelles in water. HEHDO-star-mPEG micelle showed excellent stability with respect to micellar size upon dilution, and displayed good cell-biocompatibility. An anticancer drug of doxorubicin with hydrogen-bonding functionality was incorporated into obtained micelles to establish a drug delivery system model. A high drug-loading content as well as sustained release pattern for HEHDO-star-mPEG based delivery system was achieved.

Isocyanate‐Free Approach to Water‐Borne Polyurea Dispersions and Coatings

“…1 HNMR (400 MHz, CDCl 3 , d in ppm): 4.86 (s, broad, 2H,NH), 3.63 (s, 6H, ÀCH 3 ), 3.16 (m, 4H,N HCH 2 ), 1.51 (m, 4H,N HCH 2 CH 2 ). 13 [20] In a2 000 mL three-neck flask equipped with ac ondenser,I PDA (170 g, 1mol), DMC (630 g, 7mol), and sodium methoxide (70 g, 1mol) were mixed under argon flow and stirred at room temperature. After 4h,t he mixture was heated up to 60 8Cf or 6h.T he solution was then cooled down to ca.…”

“…Most of the isocyanate‐free routes are based on cyclic species such as cyclic carbonates or cyclic urethanes and ureas . For example, Sabnis and co‐workers described the preparation of epoxy‐containing PUR coatings from propylene carbonate, ethylene diamine, and commercial epoxy monomers .…”

“…Most of the isocyanate-free routes are based on cyclic speciess uch as cyclic carbonates or cyclic urethanes and ureas. [9][10][11][12][13][14][15][16][17] For example, Sabnis and co-workers described the preparation of epoxy-containing PUR coatingsf rom propylene carbonate, ethylene diamine, and commercial epoxy monomers. [14] Cornille et al also indicated that the synthesis of cyclic Here, an isocyanate-free approacht op roduce polyureasf rom diaminesa nd dicarbamatesa sm onomers is reported.…”

Branched aliphatic polyesters by ring-opening (co)polymerization

“…Feng described the polymerization of another six-membered cyclic carbonate bearing a hydroxyl group, i.e., 5-ethyl-5-hydroxymethyl-1,3-dioxan-2-one (EHDO, IX) [86]. The polymerization mechanism was discussed.…”

Doxorubicin-loaded aromatic imine-contained amphiphilic branched star polymer micelles: synthesis, self-assembly, and drug delivery

“…[2][3][4][5][6] Various architectural polymers including linear polymers, dendrimers, hyperbranched polymers, and dendronized polymers have been utilized to construct nanocarriers. [7][8][9][10][11] Compared to the linear polymers, branched polymers possess some advantages, including a number of surface groups and hollow voids of the branching architecture, which make them attractive in drug delivery applications.…”