Hyperbilirubinemia with Urinary Tract Infection in Infants Younger than Eight Weeks Old

Rashed, Yasser K.; Khtab, Ahmad A.; Alhalaby, Ahmad M.

doi:10.12970/2308-6483.2014.02.03.4

Cited by 2 publications

(9 citation statements)

References 11 publications

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“…In most of the studies investigating the relationship between UTI and neonatal jaundice, male sex was a significant risk factor compared with female sex in the neonatal period. 8 , 9 , 19 , 20 In accordance with these studies reported, most of the cases (23 of 26) with both UTI and significant hyperbilirubinemia in our study were men. Ghaemi et al 9 have reported that 60% of their male cases with UTI were not circumcised, and Singh-Grewal et al 18 have reported that circumcision significantly reduces the risk of UTI.…”

Section: Discussionsupporting

confidence: 91%

“…In infants with UTI, the prevalence of pyuria has reportedly been 58.3%, 52%, and 33% in 3 different studies, respectively. 4 , 8 , 11 In our study, pyuria was present in 15.3% of 26 newborns with UTI.…”

Section: Discussionsupporting

confidence: 54%

“…2 The physiopathologic relationship between neonatal jaundice and UTI has always gained much interest and recently been investigated in various studies. However, this relationship has been preferably studied in newborns with late (≥8 days) jaundice, 3 – 6 prolonged jaundice (≥15 days), 5 , 7 – 9 or conjugated hyperbilirubinemia, 5 and only few studies among newborns with early (≤7 days) jaundice have been conducted. 2 , 10 , 11 Currently, authorized international institutions, such as American Academy of Pediatrics, do not recommend investigation of UTI with urinalysis or urine culture as part of investigations for the etiology of either early or late/prolonged neonatal jaundice.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Özcan

Sarıcı

Yurdugül

et al. 2017

Clin Med Insights Pediatr

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Background and purpose:Etiologic role, incidence, demographic, and response-to-treatment characteristics of urinary tract infection (UTI) among neonates, its relationship with significant neonatal hyperbilirubinemia, and abnormalities of the urinary system were studied in a prospective investigation in early (≤10 days) idiopathic neonatal jaundice in which all other etiologic factors of neonatal hyperbilirubinemia were ruled out.Patients and methods:Urine samples for microscopic and bacteriologic examination were obtained with bladder catheterization from 155 newborns with early neonatal jaundice. Newborns with a negative urine culture and with a positive urine culture were defined as group I and group II, respectively, and the 2 groups were compared with each other.Results:The incidence of UTI in whole of the study group was 16.7%. Serum total and direct bilirubin levels were statistically significantly higher in group II when compared with group I (P = .005 and P = .001, respectively). Decrease in serum total bilirubin level at the 24th hour of phototherapy was statistically significantly higher in group I compared with group II (P = .022).Conclusions:Urinary tract infection should be investigated in the etiologic evaluation of newborns with significant hyperbilirubinemia. The possibility of UTI should be considered in jaundiced newborns who do not respond to phototherapy well or have a prolonged duration of phototherapy treatment.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Özcan

Sarıcı

Yurdugül

et al. 2017

Clin Med Insights Pediatr

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“…In this study, the proportion of UTI among the jaundiced subjects after exclusion of all other etiologies of hyperbilirubinemia was 25%, which agrees with the studies done in Lebanon and Egypt by Omar et al [24] and Rashed et al [9]. They reported UTI prevalence rates of 21% and 25%, respectively.…”

Section: Discussionsupporting

confidence: 90%

“…Findings from this study may help to improve hospital care for NICU patients. As well as It may potentially help NICU authorities to consider the study findings in reallocation of health care resources to reduce infant mortality through setting up more effective early intervention measures in a neonate's clinic [9]. Providing the NICU staff with clear insights in the light of current proper clinical and epidemiological studies could help them to identify jaundiced neonates who are needed early urine culture with rapid treatment approaches [10].…”

Section: Introductionmentioning

confidence: 99%

Prediction of Urinary Tract Infection in Neonates with Unexplained Indirect Hyperbilirubinemia

Abdelrheem

Aly

Diab

et al. 2022

Open Access Maced J Med Sci

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Background: Neonates with urinary tract infection (UTI) are susceptible to higher rates of morbidity and mortality, specifically when presented with hyperbilirubinemia. Screening for UTIs in jaundiced neonates is a cost-effective strategy. The aims of this study were to investigate the pattern of UTI (prevalence, etiology, and susceptible antimicrobial agents) in neonates admitted to the NICU with unexplained indirect hyperbilirubinemia, as well as to identify early predictors of UTI in order to reduce the present morbidity and long-term consequences in NICU patients. . Methods: A cross-sectional hospital-based study that included 140 neonates diagnosed with unexplained indirect hyperbilirubinemia in the first 4 weeks of life. A questionnaire was applied to obtain demographic and clinical data. A number of laboratory parameters were assessed with clinical examination. Bacterial growth of 1 × 103 colony-forming units/mL of a single uropathogen was used to identify the existence of UTI. Multivariate analysis was used to identify the predicting factors of UTIs. Results: In the NICU group investigated, 25.7% of subjects had a culture-proved UTI. The most frequently isolated organism was Escherichia coli. Amikacin was the most common antibiotic that the isolates were susceptible to. In multivariable logistic regression analysis, a positive urine culture was statistically associated with an increase in WBCs (OR= 6.90, p= 0.001), pyuria (OR= 5.55, p= 0.001), small for gestational age (OR= 4.07, p= 0.021), prolonged phototherapy duration (OR= 3.50, p= 0.034), and the presence of obstetric complications (OR= 2.92, p= 0.001). Conclusion: UTI is substantially prevalent among neonates admitted to the NICU with unexplained indirect hyperbilirubinemia. The importance of routine UTI screening (urine culture) as part of the clinical assessment of unexplained hyperbilirubinemia was highlighted in this study, particularly in neonates with leukocytosis, pyuria, small for gestational age, prolonged phototherapy, and those born from mothers with a history of obstetric complications.

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Hyperbilirubinemia with Urinary Tract Infection in Infants Younger than Eight Weeks Old

Cited by 2 publications

References 11 publications

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections

Prediction of Urinary Tract Infection in Neonates with Unexplained Indirect Hyperbilirubinemia

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