Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord

Fu, Huiqun; Li, Fenghua; Thomas, S.; Yang, Zhong-Jin

doi:10.1016/j.sjpain.2017.08.014

Cited by 33 publications

(36 citation statements)

References 54 publications

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“…In addition, the effect of Sal B on neural cell apoptosis was evaluated. Induction of cell apoptosis, which enhances the loss of neurons and reduces neuronal functional recovery, has been widely reported following SCI (26,27). In the present study, western blot analysis determined that the expression levels of Bax, cleaved caspase-3 and cleaved caspase-9 were increased in spinal cord tissues following SCI but the expression of Bcl-2 decreased.…”

Section: Discussionsupporting

confidence: 47%

Salvianolic acid B activates Wnt/β‑catenin signaling following spinal cord injury

et al. 2019

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Neural cell apoptosis serves a key role in spinal cord injury (SCI), which is a threat to human health. The present study aimed to evaluate the neuroprotective mechanism of salvianolic acid B (Sal B) in a spinal cord injury (SCI) rat model. Basso, Beattie, and Bresnahan scores demonstrated that Sal B treatment significantly increased locomotor functional recovery in SCI rats compared with SCI model rats between 3 and 8 weeks. Nissl staining demonstrated that Sal B enhanced motor neuron survival and decreased lesion size after SCI. Reverse transcription-quantitative PCR analysis demonstrated that Sal B treatment significantly enhanced the mRNA levels of lymphoid enhancer biding factor-1 and HNF1 homeobox A. In addition, Sal B treatment enhanced the expression of β-catenin. Western blot analysis determined that Sal B treatment significantly decreased the expression of pro-apoptosis proteins, including Bax, cleaved caspase-3 and-9, in spinal cord tissues after SCI but enhanced the expression of Bcl-2, an anti-apoptotic protein. Furthermore, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining demonstrated that, compared with the SCI group, Sal B treatment decreased the number of TUNEL-positive neurons. In summary, the present study produced novel data demonstrating the neuroprotective effect of Sal B on SCI with the mechanism likely primarily mediated via the Wnt/β-catenin signaling pathway. The present findings may be of potential therapeutic value for future SCI treatments.

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Section: Discussionsupporting

confidence: 47%

Salvianolic acid B activates Wnt/β‑catenin signaling following spinal cord injury

et al. 2019

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“…Impaired tissue oxygen saturation in patients with CRPS 1 [ 50 ] may be associated with pain levels in CRPS. Indeed, hyperbaric oxygen therapy significantly alleviated mechanical allodynia, suggesting the inhibitory role of hyperbaric oxygen therapy in GABAergic neuron apoptosis suppresses ongoing neuropathic pain [ 51 ]. In other words, while high levels of oxygen may reduce pain levels, high CO 2 levels may increase sensory pain levels, affecting the synergic boost of neuropsychiatric symptoms such as depression, anxiety and suicidal ideation in CRPS patients.…”

Section: Discussionmentioning

confidence: 99%

Peripheral and Central Metabolites Affecting Depression, Anxiety, Suicidal Ideation, and Anger in Complex Regional Pain Syndrome Patients Using a Magnetic Resonance Spectroscopy: A Pilot Study

Jung

Kim

Jeon

et al. 2018

Psychiatry Investig

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Objective This study investigated peripheral and central metabolites affecting depression, anxiety, suicidal ideation, and anger in complex regional pain syndrome (CRPS) patients. Methods Metabolite levels were determined in the right and left thalamus and insula, in 12 CRPS patients using magnetic resonance spectroscopy (MRS). Results There were positive correlations between valine (Val)/tNAA (N-acetylaspartate+N-acetylaspartylglutamate) and the anxiety, and a negative correlation between glutamine (Gln)/NAA and the depression. There were positive correlations between alanine (Ala)/Gln and the depression and suicidal ideation, between glutamate (Glu)/Gln and the depression and suicidal ideation, between N-acetylaspartylglutamate (NAAG)/Gln and the depression. There was a positive correlation between Ala/NAAG and the trait anger and a negative correlation between creatine (Cr)/N-acetylaspartate (NAA) and the trait anger. There was a negative correlation between Cr/Glx (Glu+Gln) and the trait anger. High hemoglobin and alkaline phosphatase were associated with low pain levels, but CO2 and chloride showed positive correlations with pain levels in CRPS patients. Peripheral glucose, CO2 and chloride were associated with depression, anxiety, anger and suicidal ideation. Conclusion The specific central and peripheral metabolites were associated with psychological disorders including depression, anxiety, suicidal ideation and anger in CRPS patients, showing pathological interactions between a painful body and mind.

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“…However, HBOT must be administered during the small reperfusion window, which creates a limited opportunity for effective treatment. This has been a reoccurring problem with HBOT because of the difficulty associated with determining the reperfusion window and extensive imaging to determine the appropriate course of action [ 15 ]. Evidently, some studies indicate that delayed HBOT past the effective window of treatment actually causes worse outcomes.…”

Section: Hbot In Ischemic Stroke: Potential Benefits and Limitatiomentioning

confidence: 99%

“…HBOT is highly effective when administered 30 to 60 min after stroke, and the potency of treatment lessens if initiation is delayed any further. HBOT exhibits therapeutic potential in its ability to reduce infarct volume and improve behavioral scores in patients [ 14 , 15 ]. Research has demonstrated different time points at which HBOT is effective, such as HBOT (2.5 ATA for 2 h) at 6 h after reperfusion [ 35 ], and HBOT (3 ATA, 1 h) at 3 and 6 h after reperfusion [ 36 ].…”

Section: Hbot In Ischemic Stroke: Potential Benefits and Limitatiomentioning

confidence: 99%

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

et al. 2020

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Stroke serves as a life-threatening disease and continues to face many challenges in the development of safe and effective therapeutic options. The use of hyperbaric oxygen therapy (HBOT) demonstrates pre-clinical effectiveness for the treatment of acute ischemic stroke and reports reductions in oxidative stress, inflammation, and neural apoptosis. These pathophysiological benefits contribute to improved functional recovery. Current pre-clinical and clinical studies are testing the applications of HBOT for stroke neuroprotection, including its use as a preconditioning regimen. Mild oxidative stress may be able to prime the brain to tolerate full extensive oxidative stress that occurs during a stroke, and HBOT preconditioning has displayed efficacy in establishing such ischemic tolerance. In this review, evidence on the use of HBOT following an ischemic stroke is examined, and the potential for HBOT preconditioning as a neuroprotective strategy. Additionally, HBOT as a stem cell preconditioning is also discussed as a promising strategy, thus maximizing the use of HBOT for ischemic stroke.

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Hyperbaric oxygenation alleviates chronic constriction injury (CCI)-induced neuropathic pain and inhibits GABAergic neuron apoptosis in the spinal cord

Abstract: Increased apoptotic GABAergic neurons induced by activation of key proteins of mitochondrial apoptotic pathways in the dorsal horn of the spinal cord is critical in CCI-induced neuropathic pain. The inhibitory role of HBO in GABAergic neuron apoptosis suppresses ongoing neuropathic pain.

Cited by 33 publications

References 54 publications

Salvianolic acid B activates Wnt/β‑catenin signaling following spinal cord injury

Salvianolic acid B activates Wnt/β‑catenin signaling following spinal cord injury

Peripheral and Central Metabolites Affecting Depression, Anxiety, Suicidal Ideation, and Anger in Complex Regional Pain Syndrome Patients Using a Magnetic Resonance Spectroscopy: A Pilot Study

An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic

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