Hyperbaric oxygen treatment for non-arteritic central retinal artery occlusion retrospective comparative analysis from two tertiary medical centres

Rozenberg, Assaf; Hadad, Aviel; Peled, Alon; Dubinsky‐Pertzov, Biana; Or, Lior; Eting, Eva; Efrati, Shai; Pras, Eran; Einan‐Lifshitz, Adi

doi:10.1038/s41433-021-01617-8

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Likewise, comparison of changes in the VA from initial to final presentation yields similar results, with no statistical significance ( p = 0.52) between the HBOT and control groups ( Fig. 2B ) [ 9 – 11 ].…”

Section: Resultsmentioning

confidence: 60%

“…Therefore, it is still possible that there might be beneficial effects from very early administration of HBOT. Indeed, of the three studies selected in our meta-analysis, the visual benefits became more evident with earlier treatments, where Rozenberg et al [ 11 ] and Beiran et al [ 9 ] report significant improvement in the final VA with time elapse of 9 and <8 hours, respectively. A similar conclusion is also drawn in a randomized controlled trial for CRAO patients undergoing intravenous tissue-type plasminogen activator, where despite overall negative results, subgroup analysis of data demonstrates beneficial visual outcome in patients who received intravenous tissue-type plasminogen activator within 6 hours of symptoms onset [ 5 ].…”

Section: Discussionmentioning

confidence: 86%

“…Comparison of results for the selected articles demonstrate that HBOT (n = 207) does not provide a significant improvement in final VA ( p = 0.83) over the control (n = 89) group, as demonstrated in Fig. 2A [ 9 – 11 ]. Likewise, comparison of changes in the VA from initial to final presentation yields similar results, with no statistical significance ( p = 0.52) between the HBOT and control groups ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…1 flow chart, among 376 articles screened for eligibility, three articles met the final inclusion criteria for the qualitative assessment role of HBOT in CRAO patients. The relevant information from each article is summarized in Table 1 [ 9 – 11 ]. The same table also includes information from retrospective analysis of results at our own university hospital (“Current study”).…”

Section: Resultsmentioning

confidence: 99%

“…It is worth noting that the heterogeneity test for the selected studies ( Fig. 2 ) yielded a p -value of <0.1, indicating inconsistency in the reported outcomes [ 9 – 11 ]. This discrepancy is most likely attributed to large differences in the baseline visual acuities in different studies, which, despite not significantly different at baseline within each study, might attribute to a source of meta-analysis conclusion bias due to large variations across studies.…”

Section: Resultsmentioning

confidence: 99%

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The Effects of Hyperbaric Oxygen Therapy in Patients with Central Retinal Artery Occlusion: A Retrospective Study, Systematic Review, and Meta-analysis

Rosignoli¹,

Chu²,

Carter³

et al. 2022

Korean J Ophthalmol

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Purpose: Central retinal artery occlusion (CRAO) is a vision-threatening condition with a potentially poor visual prognosis. Many different treatment modalities are suggested but controversy remains regarding effectiveness of these treatments. The purpose of this study is to perform a systematic review and meta-analysis in addition to analyzing retrospective data at our own tertiary care center regarding effectiveness of hyperbaric oxygen therapy (HBOT) in treatment of CRAO.Methods: The PubMed, Scopus, and the Cochrane Library are searched from the date of database inception to September 2021 to conduct a review based on the PRISMA (preferred reporting items for systematic review and meta-analysis), evaluating the role of HBOT in visual recovery of CRAO patients. In addition, a retrospective chart review of patients clinically diagnosed with CRAO at our university-based hospital (University of Texas Health, San Antonio, TX, USA) from year 2011 to 2021 was conducted.Results: After a review of 376 articles, three articles met the inclusion criteria for meta-analysis, where a total of 207 patients received HBOT versus 89 patients that did not receive any form of oxygen therapy. Analysis of these results demonstrate that HBOT in CRAO patients does not enhance the final visual outcome (p; = 0.83). Similar conclusion was also drawn from retrospective analysis of 48 patients (15 HBOT versus 33 controls) at our tertiary care center, where no visual benefit was observed in the HBOT group.Conclusions: HBOT does not appear to improve final visual outcome and concerns remain regarding adverse reactions such as barotrauma and generalized seizures. Large, randomized studies are required for further understanding of the role of HBOT in treatment of CRAO.

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Section: Resultsmentioning

confidence: 60%