Hyperbaric Oxygen Therapy: Past, Present and Future Indications

Bakker, Diane

doi:10.1007/978-1-4615-3428-0_8

Cited by 18 publications

(16 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hyperbaric oxygen therapy (HOT) favors repair of the microcirculation and is used for the treatment of various diseases, including sensorineural hearing loss [2]. Also, some studies have pointed out that HOT improves corticotherapy and functions as a protective agent against cisplatin ototoxicity [8,14,26].…”

Section: Introductionmentioning

confidence: 99%

Effects of hyperbaric oxygen treatment on auditory hair cells after acute noise damage

Colombari

Rossato

Féres

et al. 2010

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Acute acoustic trauma (AAT) is a sudden sensorineural hearing loss caused by exposure of the hearing organ to acoustic overstimulation, typically an intense sound impulse, hyperbaric oxygen therapy (HOT), which favors repair of the microcirculation, can be potentially used to treat it. Hence, this study aimed to assess the effects of HOT on guinea pigs exposed to acoustic trauma. Fifteen guinea pigs were exposed to noise in the 4-kHz range with intensity of 110 dB sound level pressure for 72 h. They were assessed by brainstem auditory evoked potential (BAEP) and by distortion product otoacoustic emission (DPOAE) before and after exposure and after HOT at 2.0 absolute atmospheres for 1 h. The cochleae were then analyzed using scanning electron microscopy (SEM). There was a statistically significant difference in the signal-to-noise ratio of the DPOAE amplitudes for the 1- to 4-kHz frequencies and the SEM findings revealed damaged outer hair cells (OHC) after exposure to noise, with recovery after HOT (p = 0.0159), which did not occur on thresholds and amplitudes to BAEP (p = 0.1593). The electrophysiological BAEP data did not demonstrate effectiveness of HOT against AAT damage. However, there was improvement of the anatomical pattern of damage detected by SEM, with a significant reduction of the number of injured cochlear OHC and their functionality detected by DPOAE.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of hyperbaric oxygen treatment on auditory hair cells after acute noise damage

Colombari

Rossato

Féres

et al. 2010

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…HBO is used for the treatment of various inflammatory diseases and ischemic conditions (Cohn 1986;Gabb et al 1987;Grim et al 1989). Although HBO therapy is a useful method for treating various clinical conditions such as wound healing, carbon monoxide poisoning, and acute necrotizing infections (Bakker 1992;Fitzpatrick 1994), it can also cause some side effects including barotraumas (sinus and middle air barotrauma, tympanic membrane rupture, pneumothorax, air embolism due to pulmonary barotrauma), oxygen toxicity (Central nervous toxic reactions, pulmonary toxic reactions), reversible visual change and claustrophobia (Gabb et al 1987;Grim et al 1989;Bakker 1992;Hampson 1999;Chavko 2001). The role of HBO therapy in free radicalmediated tissue injury and oxidant/antioxidant metabolism is controversial and its effect on hepatic regeneration are not known (Monstrey et al 1997).…”

mentioning

confidence: 99%

The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats

Özden

Uzun

Bohloli

et al. 2004

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

The effects of hyperbaric oxygen (HBO) therapy on oxidant/antioxidant metabolism are controversial and its effects on hepatic regeneration are not known. In this study, we investigated a possible beneficial effect of HBO therapy on oxidant and antioxidants levels during liver regeneration. To conduct this study, seventy percent hepatectomy was performed on forty-eight SpraggueDawley rats and the rats were divided into two equal groups: HBO-treated group and untreated group (non-HBO group). We determined the levels of malondialdehyde (MDA), an oxidative stress marker, and the levels of antioxidant enzymes/reagents, including glutathione (GSH), superoxide dismutase (SOD) activitiy, copper (Cu) and zinc (Zn), in the remnant liver samples. We also measured mitotic index (MI) and proliferating cell nuclear antigen (PCNA) levels to assess the degree of liver regeneration. HBO treatment significantly decreased MDA levels, whereas it increased SOD activity, GSH and Zn levels. In contrast, Cu levels were lower in the HBO-treated livers than the levels in the untreated remnant livers. The effect of HBO treatment may be mediated by the suppression of certain enzymes that are responsible for lipid peroxidation. In addition, HBO treatment may induce the production of antioxidant enzymes/reagents by remnant liver tissues. The HBO-treated rats maintained their body weights but the untreated rats lost body weights. HBO treatment also increased MI and PCNA levels, indicating HBO treatment enhances liver regeneration. These

show abstract

“…Hyperbaric oxygen (HBO) has been successfully used for the treatment of various clinical conditions, including decompression sickness, soft tissue infections, wound healing, carbon monoxide intoxication [1] . Additionally, there is increasing evidence of benefi cial effects of HBO on infl ammatory and infectious diseases [2] .…”

Section: Introductionmentioning

confidence: 99%

Influence of Vitamin C and E Supplementation on Oxidative Stress Induced by Hyperbaric Oxygen in Healthy Men

Bader¹,

Bosy‐Westphal²,

Koch³

et al. 2006

Ann Nutr Metab

View full text Add to dashboard Cite

Aim: To investigate the effect of a 4-week vitamin C and E supplementation on oxidative stress induced by hyperbaric oxygen (HBO). Methods: 19 healthy men were exposed to 3 sequential protocols, i.e. HBO (100% O₂, 2.4 bar, 131 min) before (T1) and after 4 weeks of daily supplementation with 500 mg slow-release vitamin C and 272 IU vitamin E (T2). A normoatmospheric protocol (21% O₂, 1.0 bar, 131 min) served as control treatment (nonexposed). Blood samples were taken before (B) and immediately after (A) treatment. Plasma levels of vitamin A, C, E, β-carotene, reduced glutathione and malondialdehyde were measured by HPLC. Antioxidative capacity and lipid peroxides in plasma were analyzed by ELISA. Results: HBO decreased vitamin C and antioxidative capacity (T1). At T1, Δ A – B of vitamin C and lipid peroxides was different from nonexposed. Vitamin supplementation increased plasma levels of vitamin C and E by 28 and 37%, respectively. Vitamin supplementation led to decreased concentrations of lipid peroxides and reduced glutathione. After supplementation, HBO decreased vitamin C and reduced glutathione. At T2, Δ A – B of vitamin C and lipid peroxides was significantly different from nonexposed. Conclusion: In humans, oxidative stress decreased plasma levels of vitamin C and antioxidative capacity and increased plasma lipid peroxides. Supplementation with vitamin C and E did not prevent these effects.

show abstract

Hyperbaric Oxygen Therapy: Past, Present and Future Indications

Cited by 18 publications

References 5 publications

Effects of hyperbaric oxygen treatment on auditory hair cells after acute noise damage

Effects of hyperbaric oxygen treatment on auditory hair cells after acute noise damage

The Effects of Hyperbaric Oxygen Treatment on Oxidant and Antioxidants Levels during Liver Regeneration in Rats

Influence of Vitamin C and E Supplementation on Oxidative Stress Induced by Hyperbaric Oxygen in Healthy Men

Contact Info

Product

Resources

About