Hyperbaric Oxygen Therapy in Orthopedic Conditions: An Evaluation of Safety

Huang, Kuo Chin; Hsu, Wei Hsiu; Peng, Kuo Ti; Huang, Tiao‐Lai; Hsu, Robert Wen Wei

doi:10.1097/01.ta.0000196702.26858.56

Cited by 12 publications

(8 citation statements)

References 14 publications

(18 reference statements)

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“…However, the delayed consolidation or non-consolidation of fractures has significant financial impacts on society and represents a serious clinical challenge for which few treatment options are available. Various, often necessary surgical procedures are accompanied with patient morbidity and reduced quality of life (11). …”

Section: Introductionmentioning

confidence: 99%

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Neves¹,

Abib²,

Neves³

et al. 2013

Clinics

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OBJECTIVES:The purpose is to study the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing the fibula bone of rabbits after induced fractures.METHODS:A total of 128 male New Zealand albino rabbits, between 6–8 months old, were subjected to a total osteotomy of the proximal portion of the right fibula. After surgery, the animals were divided into four groups (n = 32 each): control group, in which animals were subjected to osteotomy; autologous platelet concentrate group, in which animals were subjected to osteotomy and autologous platelet concentrate applied at the fracture site; hyperbaric oxygen group, in which animals were subjected to osteotomy and 9 consecutive daily hyperbaric oxygen therapy sessions; and autologous platelet concentrate and hyperbaric oxygen group, in which animals were subjected to osteotomy, autologous platelet concentrate applied at the fracture site, and 9 consecutive daily hyperbaric oxygen therapy sessions. Each group was divided into 4 subgroups according to a pre-determined euthanasia time points: 2, 4, 6, and 8 weeks postoperative. After euthanasia at a specific time point, the fibula containing the osseous callus was prepared histologically and stained with hematoxylin and eosin or picrosirius red.RESULTS:Autologous platelet concentrates and hyperbaric oxygen therapy, applied together or separately, increased the rate of bone healing compared with the control group.CONCLUSION:Hyperbaric oxygen therapy and autologous platelet concentrate combined increased the rate of bone healing in this experimental model.

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Section: Introductionmentioning

confidence: 99%

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Neves¹,

Abib²,

Neves³

et al. 2013

Clinics

View full text Add to dashboard Cite

show abstract

“…This remedy is usually employed for conditions such as carbon monoxide poisoning, limb arterial occlusive diseases, diseases of the central nervous system, sudden deafness, and retinal arterial occlusion. Recently, its application has been expanded to multiple fields including orthopedics [8, 9] and sports medicine [10, 11]. We have proposed the possibility that HBOT would be effective in the treatment of autoimmune diseases and hematopoietic malignancies [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis

Tsuneyama

Chen

Fujimoto

et al. 2011

The Scientific World JOURNAL

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The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase). Interestingly, the body weight of the HBOT group was significantly lower (P < 0.01) than that of the control group. In contrast, the serum lipid level did not show significant changes between the two groups. As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.

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“…Regarding HBOT potential risks, this therapy has been shown to be extremely safe during the treatment of several pathologies (Heyboer et al, 2017; Kanhai & Losito, 2003; M. S. Leite et al, 2010; D. Zhao et al, 2017), including orthopedic conditions (Huang et al, 2006). Most complications are minor and reversible.…”

Section: Safety Risks and Uncertainties Of Hbotmentioning

confidence: 99%

Revisiting the role of hyperbaric oxygen therapy in knee injuries: Potential benefits and mechanisms

Leite

Tavares

Leite

et al. 2023

Journal Cellular Physiology

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Knee injury negatively impacts routine activities and quality of life of millions of people every year. Disruption of tendons, ligaments, and articular cartilage are major causes of knee lesions, leading to social and economic losses. Besides the attempts for an optimal recovery of knee function after surgery, the joint healing process is not always adequate given the nature of intra-articular environment. Based on that, different therapeutic methods attempt to improve healing capacity. Hyperbaric oxygen therapy (HBOT) is an innovative biophysical approach that can be used as an adjuvant treatment post-knee surgery, to potentially prevent chronic disorders that commonly follows knee injuries. Given the well-recognized role of HBOT in improving wound healing, further research is necessary to clarify the benefits of HBOT in damaged musculoskeletal tissues, especially knee disorders. Here, we review important mechanisms of action for HBOT-induced healing including the induction of angiogenesis, modulation of inflammation and extracellular matrix components, and activation of parenchyma cells-key events to restore knee function after injury. This review discusses the basic science of the healing process in knee injuries, the role of oxygen during cicatrization, and shed light on the promising actions of HBOT in treating knee disorders, such as tendon, ligament, and cartilage injuries.

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Hyperbaric Oxygen Therapy in Orthopedic Conditions: An Evaluation of Safety

Cited by 12 publications

References 14 publications

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis

Revisiting the role of hyperbaric oxygen therapy in knee injuries: Potential benefits and mechanisms

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